Introduction：Basic information about CAS 28319-77-9|Choline glycerophosphate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Choline glycerophosphate |
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| CAS Number | 28319-77-9 | Molecular Weight | 257.221 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C8H20NO6P | Melting Point | -98ºC |
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| MSDS | USA | Flash Point | 11 °C |
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Names
| Name | choline alfoscerate |
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| Synonym | More Synonyms |
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Choline glycerophosphate BiologicalActivity
| Description | L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>AChENatural Products >>OthersResearch Areas >>Neurological Disease |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9. [2]. Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69. |
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Chemical & Physical Properties
| Melting Point | -98ºC |
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| Molecular Formula | C8H20NO6P |
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| Molecular Weight | 257.221 |
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| Flash Point | 11 °C |
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| Exact Mass | 257.102814 |
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| PSA | 108.86000 |
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| LogP | -5.63 |
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| Appearance of Characters | solid |
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| Index of Refraction | 1.329 (20ºC) |
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| InChIKey | SUHOQUVVVLNYQR-MRVPVSSYSA-N |
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| SMILES | C[N+](C)(C)CCOP(=O)([O-])OCC(O)CO |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KH2775000
- CHEMICAL NAME :
- Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N, N-trimethyl-, hydroxide, inner salt, (R)-
- CAS REGISTRY NUMBER :
- 28319-77-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H20-N-O6-P
- MOLECULAR WEIGHT :
- 257.26
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >13 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >650 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553
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Safety Information
| Hazard Codes | F: Flammable;T: Toxic; |
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| Risk Phrases | R11 |
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| Safety Phrases | S16-S36/37-S45 |
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| RIDADR | UN 1230 3/PG 2 |
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| WGK Germany | 2 |
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| RTECS | KH2775000 |
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| Packaging Group | II |
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| HS Code | 2923900090 |
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Customs
| HS Code | 2923900090 |
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| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| L-α-Glycerophosphocholine |
| α-GPC |
| Ethanaminium, 2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt |
| L-a-Glycerylphosphorylcholine |
| L-α-Glycerophosphorylcholine |
| Choline Alfoscerate |
| cholini alfosceras |
| (R)-2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium hydroxide inner salt |
| sn-Glycero-3-phosphocholine |
| (2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphate |
| MFCD00063544 |
| alfoscerato de colina |
| EINECS 248-962-2 |
| alfoscerate de choline |
| L-α Glycerylphosphorylcholine |
| L-a-GPC |
| sn-Glycero-3-phosphorylcholine |
| Choline glycerophosphate |
