CAS 2426-07-5|1,2,7,8-Diepoxyoctane
Introduction：Basic information about CAS 2426-07-5|1,2,7,8-Diepoxyoctane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,2,7,8-Diepoxyoctane | ||
|---|---|---|---|
| CAS Number | 2426-07-5 | Molecular Weight | 142.196 |
| Density | 0.997 | Boiling Point | 240.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H14O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 98 ºC |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 1,2,7,8-Diepoxyoctane |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 0.997 |
|---|---|
| Boiling Point | 240.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H14O2 |
| Molecular Weight | 142.196 |
| Flash Point | 98 ºC |
| Exact Mass | 142.099380 |
| PSA | 25.06000 |
| LogP | 0.86 |
| Vapour Pressure | 0.1±0.4 mmHg at 25°C |
| Index of Refraction | 1.445 |
| InChIKey | LFKLPJRVSHJZPL-UHFFFAOYSA-N |
| SMILES | C(CCC1CO1)CC1CO1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1070 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 320 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6600 mg/kg/55W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Specific locus test
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 12500 nmol/L
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),587,1979
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 12500 nmol/L
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),587,1979
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H311-H341-H350 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R22;R24;R40 |
| Safety Phrases | S36/37/39-S45 |
| RIDADR | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | RG9450000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2910900090 |
Customs
| HS Code | 2910900090 |
|---|---|
| Summary | 2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles8
More Articles| Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress. Genet. Mol. Res. 1(1) , 79-89, (2002) The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substant... | |
| Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides. Mutat. Res. 441(1) , 85-93, (1999) The time-dependent dose-response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for viability (evaluated by the MTT cytotoxic... | |
| 1,2,5,6-Diepoxyhexane and 1,2,7,8-diepoxyoctane cross-link duplex DNA at 5'-GNC sequences. Chem. Res. Toxicol. 9(6) , 994-1000, (1996) The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. T... |
Synonyms
| octane-1,2,7,8-diepoxide |
| 1,7-Octadiene Diepoxide |
| Octane,1,2:7,8-diepoxy |
| Oxirane, 2,2'-(1,4-butanediyl)bis- |
| 2,2'-Butane-1,4-diyldioxirane |
| EINECS 219-375-9 |
| MFCD00005155 |
| 2,2'-(1,4-Butanediyl)dioxirane |
| UNII:4IJ1M5W7LL |
| 1,2-Epoxy-7,8-epoxyoctane |
| 2-[4-(oxiran-2-yl)butyl]oxirane |
| Octa-1,7-diene diepoxide |
| 1,2,7,8-Octadiene bisepoxide |
