Introduction：Basic information about CAS 37860-51-8|PROTAC Linker 16, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PROTAC Linker 16 |
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| CAS Number | 37860-51-8 | Molecular Weight | 502.59800 |
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| Density | 1.242 g/mL at 25ºC(lit.) | Boiling Point | 635ºC at 760 mmHg |
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| Molecular Formula | C22H30O9S2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | >230 °F |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Tetraethylene Glycol DI-P-Tosylate |
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| Synonym | More Synonyms |
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PROTAC Linker 16 BiologicalActivity
| Description | PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.242 g/mL at 25ºC(lit.) |
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| Boiling Point | 635ºC at 760 mmHg |
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| Molecular Formula | C22H30O9S2 |
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| Molecular Weight | 502.59800 |
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| Flash Point | >230 °F |
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| Exact Mass | 502.13300 |
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| PSA | 131.19000 |
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| LogP | 4.62560 |
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| Index of Refraction | n20/D 1.53(lit.) |
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| InChIKey | SLAONPBUWDUSSO-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2909309090 |
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Customs
| HS Code | 2909309090 |
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| Summary | 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Articles1
More Articles
| Bis(isoquinoline N-oxide) pincers as a new type of metal cation dual channel fluorosensor. Org. Lett. 4(5) , 855-8, (2002) [structure: see text] A new type of donor-spacer-acceptor podand system has been synthesized and proved as an efficient dual channel fluorosensor for Li+, Mg2+, and Ca2+. The known ability for the N-o... | |
Synonyms
| TETRAETHYLENE GLYCOL DI-P-TOSYLATE |
| Tetraethylene Glycol Bis(p-toluenesulfonate) |
| Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether |
| ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| Bis[2-(2-tosyloxyethoxy)ethyl] Ether |
| MFCD00075239 |
