Introduction：Basic information about CAS 66376-36-1|Alendronic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alendronic acid |
|---|
| CAS Number | 66376-36-1 | Molecular Weight | 249.09600 |
|---|
| Density | 1.857 g/cm3 | Boiling Point | 616.7ºC at 760 mmHg |
|---|
| Molecular Formula | C4H13NO7P2 | Melting Point | 230-235ºC |
|---|
| MSDS | / | Flash Point | 326.7ºC |
|---|
Names
| Name | alendronic acid |
|---|
| Synonym | More Synonyms |
|---|
Alendronic acid BiologicalActivity
| Description | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
|---|
| In Vitro | Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2]. |
|---|
| References | [1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293. [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032. |
|---|
Chemical & Physical Properties
| Density | 1.857 g/cm3 |
|---|
| Boiling Point | 616.7ºC at 760 mmHg |
|---|
| Melting Point | 230-235ºC |
|---|
| Molecular Formula | C4H13NO7P2 |
|---|
| Molecular Weight | 249.09600 |
|---|
| Flash Point | 326.7ºC |
|---|
| Exact Mass | 249.01700 |
|---|
| PSA | 180.93000 |
|---|
| InChIKey | OGSPWJRAVKPPFI-UHFFFAOYSA-N |
|---|
| SMILES | NCCCC(O)(P(=O)(O)O)P(=O)(O)O |
|---|
Safety Information
| RIDADR | 1759 |
|---|
| RTECS | SZ6521833 |
|---|
| Packaging Group | III |
|---|
| HS Code | 2931900090 |
|---|
Customs
| HS Code | 2931900090 |
|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| (4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid |
| (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid |
