CAS 26787-78-0|Amoxicillin
Introduction：Basic information about CAS 26787-78-0|Amoxicillin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amoxicillin | ||
|---|---|---|---|
| CAS Number | 26787-78-0 | Molecular Weight | 365.404 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 701.8±70.0 °C at 760 mmHg |
| Molecular Formula | C16H19N3O5S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 378.2±35.7 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | amoxicillin |
|---|---|
| Synonym | More Synonyms |
Amoxicillin BiologicalActivity
| Description | Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
| References | [1]. http://en.wikipedia.org/wiki/Amoxicillin |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 701.8±70.0 °C at 760 mmHg |
| Molecular Formula | C16H19N3O5S |
| Molecular Weight | 365.404 |
| Flash Point | 378.2±35.7 °C |
| Exact Mass | 365.104553 |
| PSA | 158.26000 |
| LogP | 0.92 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.745 |
| InChIKey | LSQZJLSUYDQPKJ-NJBDSQKTSA-N |
| SMILES | CC1(C)SC2C(NC(=O)C(N)c3ccc(O)cc3)C(=O)N2C1C(=O)O |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 40 mg/kg/4D
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 682 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria
- REFERENCE :
- CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition
- REFERENCE :
- CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2870 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >25 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3590 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
- REFERENCE :
- CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 7-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R42/43 |
| Safety Phrases | S22-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XH8300000 |
| HS Code | 2941109200 |
Customs
| HS Code | 2941109200 |
|---|
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Synonyms
| Intermox |
| Lamoxy |
| A-Gram |
| Novenzymin |
| Amoxin |
| Amoxtrex |
| AMOX |
| Amoxa |
| Imaxilin |
| Uro-clamoxyl |
| Imox |
| Rancil |
| Moxylin |
| Ampidroxyl |
| MOx |
| Excillin |
| Tolodina |
| [2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| Protexillin |
| Samosillin |
| Amoxy |
| Bridopen |
| Ranmoxy |
| Grunamox |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| Jerramcil |
| Kamoxin |
| Amoxaren |
| Zamocillin |
| Damoxicil |
| Zamocilline |
| Larocilin |
| Cilamox |
| Amoxy-diolan |
| Rhamoxilina |
| Zerrsox |
| Amoxicillin |
| Limox |
| Agerpen |
| Pasetocin |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E,2R)-2-amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| Gomcillin |
| Amoxal |
| Gemox |
| (2S,5R,6R)-6-{(E)-[(2R)-2-Amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Sigmopen |
| Amoxine |
| Comoxyl |
| Moxaline |
| Zimox |
| amoxil |
| Bioxidona |
| blp1410 |
| Amoxi-Diolan |
| Eupen |
| Alphamox |
| Azillin |
| 6-[D(-)-a-Amino-p-hydroxyphenylacetamido]penicillanic Acid |
| Zamox |
| Amoxina |
| Amagesen Solutab |
| Amoxi-basan |
| Amoxidal |
| Amoxillat |
| Suramox PM |
| amolin |
| Amoxisol |
| Amoxicillin-ratiopharm |
| Simplamox |
| Draximox |
| Amoxihexal |
| [2S,5R,6R]-6-[[[2R]-Amino[4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| Optium |
| Moxlin |
| Virgoxillin |
| Trimox |
| Mopen |
| EINECS 248-003-8 |
| Clamox |
| a-Amino-p-hydroxybenzylpenicillin |
| Amoxibiotic |
| Meixil |
| Hipen |
| Galenamox |
| Moxilen |
| Amoxipenil |
| Farconcil |
| Rocillin |
| Amosine |
| Gimalxina |
| Ciblor |
| Zamoxil |
| Anemol |
| α-Amino-p-hydroxybenzylpenicillin |
| Bioxyllin |
| PENSYN |
| Triafamox |
| Moxarin |
| amoxi |
| Morgenxil |
| Amoran |
| Moxyvit |
| Grinsul |
| p-Hydroxyampicillin |
| Amophar |
| Amopen |
| Amodex |
| (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Moxypen |
| Reloxyl |
| MFCD00072029 |
| Apo-Amoxi |
| Efpinex |
| Ikamoxil |
| Amoxi-wolff |
| Sil-A-mox |
| Audumic |
| Alfamox |
| Bimox |
| Fullcilina |
| Ospamox |
| Triamoxil |
| Teramoxyl |
| Matasedrin |
| Penbiosyn |
| Ronemox |
| Amoxivan |
| Fisamox |
| Moxcil |
| Amoxillin |
| Winmox |
| Amcill |
| Amoxapen |
| Amoxipen |
| Pamoxicillin |
| Amo-flamsian |
| Abdimox |
| Biomox |
| Novabritine |
| Himinomax |
| Pacetocin |
| Posmox |
| 6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid |
| Novamoxin |
| Yisulon |
| Ranoxyl |
| Sintopen |
| Isimoxin |
| Acimox |
| Amoxcillin |
| Samthongcillin |
| Bintamox |
| Velamox |
| Gramidil |
| clavulanate |
| Twicyl |
| Adbiotin |
| 6-(p-Hydroxy-a-aminophenylacetamido)penicillanic Acid |
| Majorpen |
| Saltermox |
| Sia-mox |
| Izoltil |
| Amoflux |
| Utimox |
| Flemoxine |
| Imoxil |
| Paradroxil |
| Foxolin |
| Hidramox |
| Pamocil |
| Specillin |
| Kentrocyllin |
| Senox |
| Actimoxi |
| Trilaxin |
| Superpeni |
| amoxycillin |
| (-)-6-[2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| Bactamox |
| Medimox |
| Sawamezin |
| Dura AX |
| Maxcil |
| Apitart |
| Coamoxin |
| Hosboral |
| sumox |
