Introduction：Basic information about CAS 98418-47-4|Metroprolol succinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Metroprolol succinate |
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| CAS Number | 98418-47-4 | Molecular Weight | 652.816 |
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| Density | / | Boiling Point | 398.6ºC at 760 mmHg |
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| Molecular Formula | C34H56N2O10 | Melting Point | / |
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| MSDS | / | Flash Point | 194.9ºC |
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| Symbol |
GHS08 | Signal Word | Danger |
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Names
| Name | butanedioic acid,1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol |
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| Synonym | More Synonyms |
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Metroprolol succinate BiologicalActivity
| Description | Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.IC50 value:Target: β1 receptor |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Cardiovascular Disease |
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| References | [1]. Benfield P, et al. Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs. 1986 May;31(5):376-429. |
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Chemical & Physical Properties
| Boiling Point | 398.6ºC at 760 mmHg |
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| Molecular Formula | C34H56N2O10 |
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| Molecular Weight | 652.816 |
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| Flash Point | 194.9ºC |
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| Exact Mass | 652.393494 |
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| PSA | 176.04000 |
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| LogP | 3.94400 |
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| InChIKey | RGHAZVBIOOEVQX-UHFFFAOYSA-N |
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| SMILES | COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc1ccc(OCC(O)CNC(C)C)cc1.O=C(O)CCC(=O)O |
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| Storage condition | -20℃ |
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| Water Solubility | Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate. |
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Safety Information
| Symbol |
GHS08 |
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| Signal Word | Danger |
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| Hazard Statements | H370 |
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| Precautionary Statements | P260 |
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| HS Code | 2922199090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles1
More Articles
| Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations. Eur. J. Pharm. Biopharm. 88(2) , 472-82, (2014) This study focused on the evaluation of prilling as a technique for the manufacturing of multiparticulate dosage forms. Prills, providing controlled and immediate drug release, were processed and fina... | |
Synonyms
| UNII:TH25PD4CCB |
| 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol butanedioate (2:1) |
| Selozok |
| 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol butanedioate (2:1) (salt) |
| Beloc-Zok |
| Succinic acid - 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol (1:2) |
| 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, butanedioate (2:1) (salt) |
| Metroprolol succinate |
| Spesicor Dos |
| 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol succinate (2:1) |
| Toprol XL |
| acide butanedioïque - 1-[4-(2-méthoxyéthyl)phénoxy]-3-[(1-méthyléthyl)amino]propan-2-ol (1:2) |
| Seloken ZOC |
| Butandisäure--1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol(1:2) |
| H 93/26 succinate |
| Metoprolol (Succinate) |
