CAS 24356-94-3|Algestone acetophenide

Introduction：Basic information about CAS 24356-94-3|Algestone acetophenide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameAlgestone acetophenide
CAS Number24356-94-3Molecular Weight448.594
Density1.2±0.1 g/cm3Boiling Point579.0±50.0 °C at 760 mmHg
Molecular FormulaC29H36O4Melting Point150 - 151ºC
MSDS/Flash Point246.7±30.2 °C

Names

Namealgestone acetophenide
SynonymMore Synonyms

Algestone acetophenide BiologicalActivity

DescriptionAlgestone acetophenide is a progesterone drug. Algestone acetophenide can be used in combination with estrogen as a long-acting injectable contraceptive[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References

[1]. Daeseleire, et al. Application of high-performance thin-layer chromatography and gas chromatography-mass spectrometry to the detection of new anabolic steroids used as growth promoters in cattle fattening. Journal of Chromatography A. 1994;674(1-2): 247–253.

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point579.0±50.0 °C at 760 mmHg
Melting Point150 - 151ºC
Molecular FormulaC29H36O4
Molecular Weight448.594
Flash Point246.7±30.2 °C
Exact Mass448.261353
PSA52.60000
LogP6.16
Vapour Pressure0.0±1.6 mmHg at 25°C
Index of Refraction1.591
InChIKeyAHBKIEXBQNRDNL-JRLVXNONSA-N
SMILESCC(=O)C12OC(C)(c3ccccc3)OC1CC1C3CCC4=CC(=O)CCC4(C)C3CCC12C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5011700
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetophenone, (R)-
CAS REGISTRY NUMBER :
24356-94-3
LAST UPDATED :
198910
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C29-H36-O4
MOLECULAR WEIGHT :
448.65
WISWESSER LINE NOTATION :
T F5 E5 B666 GO IO RV PUTJ A1 E1 FV1 H1 HR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
750 mg/kg
SEX/DURATION :
female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
240 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 10,687,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
300 mg/kg
SEX/DURATION :
female 14-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 71,448,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 mg/kg
SEX/DURATION :
female 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2250 ug/kg
SEX/DURATION :
female 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 mg/kg
SEX/DURATION :
female 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
79200 ug/kg
SEX/DURATION :
male 48 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 8,33,1966
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
396 mg/kg
SEX/DURATION :
male 48 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 8,33,1966
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
700 mg/kg
SEX/DURATION :
female 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 57,1475,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
84 mg/kg
SEX/DURATION :
female 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 57,1475,1969

Safety Information

Hazard CodesXi: Irritant;

Synonyms

Algestone acetophenide
Bovitrol
(4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
16α,17α-Dihydroxyprogesterone acetophenide
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-acetyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-4a,6a,8-trimethyl-8-phenyl-, (4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-
Algestone acetophonide
16a,17-Dihydroxypregn-4-ene-3,20-dione Cyclic Acetal with Acetophenone
Droxone
UNII:T379IG5RV1
[16a(R)]-16,17-[(1-Phenylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
MFCD00056835
Neolutin Depositum
EINECS 246-195-8
Dihydroxyprogesterone acetophenide
P-Dhp
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-acetyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-4a,6a,8-trimethyl-8-phenyl-, (4aR,4bS,6aS,6bS,9aR,10aS,10bR)-
deladroxone
16a,17a-Dihydroxyprogesterone Acetophenide
ALGESTERONE ACETOPHENIDE
(4aR,4bS,6aS,6bS,9aR,10aS,10bR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
alphasoneacetophenide
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