CAS 177325-13-2|Levofloxacin hydrochloride
Introduction：Basic information about CAS 177325-13-2|Levofloxacin hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Levofloxacin hydrochloride | ||
|---|---|---|---|
| CAS Number | 177325-13-2 | Molecular Weight | 397.828 |
| Density | / | Boiling Point | 571.5ºC at 760 mmHg |
| Molecular Formula | C18H21ClFN3O4 | Melting Point | / |
| MSDS | / | Flash Point | 299.4ºC |
Names
| Name | Levofloxacin hydrochloride |
|---|---|
| Synonym | More Synonyms |
Levofloxacin hydrochloride BiologicalActivity
| Description | Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>TopoisomeraseResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>Bacterial |
| Target | TOPO IV |
| References | [1]. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86. [2]. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014. [3]. Lee, B.T., et al., Efficacy of Levofloxacin in the Treatment of BK Viremia: A Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol, 2014. [4]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. |
Chemical & Physical Properties
| Boiling Point | 571.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C18H21ClFN3O4 |
| Molecular Weight | 397.828 |
| Flash Point | 299.4ºC |
| Exact Mass | 397.120453 |
| PSA | 75.01000 |
| LogP | 2.34890 |
| Vapour Pressure | 6.7E-14mmHg at 25°C |
| InChIKey | CAOOISJXWZMLBN-PPHPATTJSA-N |
| SMILES | CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.Cl |
Safety Information
| HS Code | 2934999090 |
|---|
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| ac-7617 |
| 7H-1,4-Oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)-, hydrochloride (1:1) |
| (3S)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride (1:1) |
| s454 |
| Levofloxacin hydrochloride |
| (3S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride (1:1) |
| EINECS 605-797-4 |
