CAS 81131-70-6|Pravastatin (sodium)

Introduction：Basic information about CAS 81131-70-6|Pravastatin (sodium), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pravastatin (sodium) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Pravastatin (sodium)
CAS Number	81131-70-6	Molecular Weight	446.51
Density	/	Boiling Point	634.5ºCat 760 mmHg
Molecular Formula	C₂₃H₃₅NaO₇	Melting Point	171.2-173 °C
MSDS	USA	Flash Point	213.2ºC

Names

Name	pravastatin sodium
Synonym	More Synonyms

Pravastatin (sodium) BiologicalActivity

Description	Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Target: HMG-CoA reductasePravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.Pravastatin is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.The evidence for the use of pravastatin is generally weaker than for other statins. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT), failed to demonstrate a difference in all-cause mortality or nonfatal myocardial infarction/fatal coronary heart disease rates between patients receiving pravastatin 40mg daily (a common starting dose) and those receiving usual care.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Research Areas >>Cardiovascular Disease
References	[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89.

Chemical & Physical Properties

Boiling Point	634.5ºCat 760 mmHg
Melting Point	171.2-173 °C
Molecular Formula	C₂₃H₃₅NaO₇
Molecular Weight	446.51
Flash Point	213.2ºC
PSA	124.29000
LogP	2.44040
InChIKey	VWBQYTRBTXKKOG-IYNICTALSA-M
SMILES	CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)[O-])C21.[Na+]
Storage condition	2-8°C
Water Solubility	H2O: 19 mg/mL

Safety Information

Hazard Codes	F: Flammable;C: Corrosive;
Risk Phrases	R11
Safety Phrases	16-26-36/37/39-45
RIDADR	3077
WGK Germany	2
RTECS	QJ7185000
Packaging Group	III
Hazard Class	9
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6S,8S,8aR)- (1:1)

1-naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[[(2S)-2-methyl-1-oxobutyl]oxy]-, monosodium salt, (βR,δR,1S,2S,6S,8S,8aR)-

Natrium-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoat

Oliprevin

Sodium (+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(S)-2-methylbutyryloxy]-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoate

MFCD00887601

Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoate

Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoate

Vasten

[1S-[1a(bS*,dS*),2a,6a,8b(R*),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid Monosodium Salt

3b-Hydroxycompactin Sodium Salt

Pravastatin sodium

Pravastatin (sodium)

Recommended......