CAS 76-02-8|Trichloroacetyl chloride
Introduction：Basic information about CAS 76-02-8|Trichloroacetyl chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trichloroacetyl chloride | ||
|---|---|---|---|
| CAS Number | 76-02-8 | Molecular Weight | 181.833 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 118.0±0.0 °C at 760 mmHg |
| Molecular Formula | C2Cl4O | Melting Point | -57 °C |
| MSDS | ChineseUSA | Flash Point | 31.0±26.5 °C |
| Symbol | GHS05, GHS06 | Signal Word | Danger |
Names
| Name | Trichloroacetyl Chloride |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 118.0±0.0 °C at 760 mmHg |
| Melting Point | -57 °C |
| Molecular Formula | C2Cl4O |
| Molecular Weight | 181.833 |
| Flash Point | 31.0±26.5 °C |
| Exact Mass | 179.870331 |
| PSA | 17.07000 |
| LogP | 2.39 |
| Vapour Pressure | 17.0±0.2 mmHg at 25°C |
| Index of Refraction | 1.501 |
| InChIKey | PVFOMCVHYWHZJE-UHFFFAOYSA-N |
| SMILES | O=C(Cl)C(Cl)(Cl)Cl |
| Stability | Stable. Reacts violently with water. Incompatible with alcohols, oxidizing agents, strong bases. |
| Water Solubility | reacts violently |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 475 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 445 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7270 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)
Safety Information
| Symbol | GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314-H330 |
| Supplemental HS | Reacts violently with water. |
| Precautionary Statements | P260-P280-P284-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T+:Verytoxic; |
| Risk Phrases | R14;R22;R26;R29;R35 |
| Safety Phrases | S26-S28-S36/37/39-S45-S8-S28A-S23 |
| RIDADR | UN 2442 8/PG 2 |
| WGK Germany | 3 |
| RTECS | AO7140000 |
| Packaging Group | II |
| Hazard Class | 8 |
| HS Code | 2914700090 |
Customs
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
Articles8
More Articles| Enantioselective synthesis of dihydro-1H-benzindoles. J. Org. Chem. 78(7) , 3379-83, (2013) The first examples of dihydro-1H-benzindoles by enantioselective γ-lactamization reaction of naphthyl sulfilimines with trichloroacetyl chloride in the presence of ZnCu as catalyst (≥98:2 er and 65-80... | |
| Synthesis of 3-alkylbenzoxazolones from N-alkyl-N-arylhydroxylamines by contiguous O-trichloroacetylation, trichloroacetoxy ortho-shift, and cyclization sequence. J. Org. Chem. 78(23) , 11935-47, (2013) Benzoxazolone pharmacophore is present in clinical pharmaceuticals, drug candidates, and many compounds having a wide spectrum of biological activities. The methods available for the synthesis of benz... | |
| Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. Chem. Biol. Interact. 116(1-2) , 123-41, (1998) Halothane hepatitis occurs because susceptible patients mount immune responses to trifluoroacetylated protein antigens, formed following cytochrome P450-mediated bioactivation of halothane to trifluor... |
Synonyms
| Trichloroacetochloride |
| Acetyl chloride, 2,2,2-trichloro- |
| Acetyl chloride, trichloro- |
| CCl3COCl |
| EINECS 200-926-7 |
| TRICHLOROACETIC ACID CHLORIDE |
| Trichloroacetyl chloride [UN2442] [Corrosive] |
| MFCD00000792 |
| Trichloroacetyl chloride |
| 2,2,2-Trichloroethanoyl chloride |
