CAS 101-61-1|4,4'-Methylenebis(N,N-dimethylaniline)

Introduction：Basic information about CAS 101-61-1|4,4'-Methylenebis(N,N-dimethylaniline), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles15
7. Synonyms

Common Name	4,4'-Methylenebis(N,N-dimethylaniline)
CAS Number	101-61-1	Molecular Weight	254.37000
Density	/	Boiling Point	390 °C
Molecular Formula	C₁₇H₂₂N₂	Melting Point	88-89 °C(lit.)
MSDS	ChineseUSA	Flash Point	178 °C
Symbol	GHS08, GHS09	Signal Word	Danger

Names

Name	4,4'-Methylenebis(N,N-dimethylaniline)
Synonym	More Synonyms

Chemical & Physical Properties

Boiling Point	390 °C
Melting Point	88-89 °C(lit.)
Molecular Formula	C₁₇H₂₂N₂
Molecular Weight	254.37000
Flash Point	178 °C
Exact Mass	254.17800
PSA	6.48000
LogP	3.40940
Vapour Pressure	5.15E-08mmHg at 25°C
Index of Refraction	1.615
InChIKey	JNRLEMMIVRBKJE-UHFFFAOYSA-N
SMILES	CN(C)c1ccc(Cc2ccc(N(C)C)cc2)cc1
Storage condition	2-8°C
Water Solubility	Insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY5250000

CHEMICAL NAME :: Aniline, 4,4'-methylenebis(N,N-dimethyl-

CAS REGISTRY NUMBER :: 101-61-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 40

MOLECULAR FORMULA :: C17-H22-N2

MOLECULAR WEIGHT :: 254.41

WISWESSER LINE NOTATION :: 1N1&R D1R DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8500 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 310 gm/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 155 gm/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 683 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1365 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15488 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7744 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rabbit Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,197,1981 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3405 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 1563 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3405 No. of Facilities: 631 (estimated) No. of Industries: 15 No. of Occupations: 9 No. of Employees: 4140 (estimated)

Safety Information

Symbol	GHS08, GHS09
Signal Word	Danger
Hazard Statements	H350-H410
Precautionary Statements	P201-P273-P308 + P313-P501
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R45;R50/53
Safety Phrases	S53-S45-S60-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	BY5250000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29215990

Customs

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles15

Disposition and metabolism of the carcinogen reduced Michler's ketone in rats.

Cancer Res. 42(9) , 3475-9, (1982)

Studies on the in vivo and in vitro disposition of 4,4'-[14C]-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK) were performed. Osborne-Mendel rats retained, after 24 hr, 78% of a p....

4,4'-Methylenebis(N,N-dimethyl)benzenamine.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 119-26, (1982)

[Antiarrhythmic effects of bis(dimethyl amino)-diphenyl methane (BDDM)].

Yao Xue Xue Bao 23(6) , 448-51, (1988)

Synonyms

N,N,N',N'-tetramethyl-4,4'-diaminodiphenylmethane

TETRA BASE

ARNOLDS BASE

4,4-METHYLENEBIS(N,N-DIMETHYLANILINE)

4,4'-BIS-(DIMETHYLAMINO)DIPHENYLMETHANE

methylenebase

4,4'-Tetramethyldiaminodiphenylmethane

4,4'- Methylenebis-(n,n-dimethylaniline)

4,4‘-Methylenebis(N,N-dimethylaniline)

METHANE BASE

4,4-METHYLENE-BISDIMETHYLANILINE

4,4'-METHYLENEBIS(N,N'-DIMETHYLANILINE)

4,4'-METHYLENEBIS

4,4'-BIS(DIMETHYLAMINO)-DIPHENYLMETHANE

Bis-(4-dimethylaminophenyl)methane

4,4-BIS(DIMETHYLAMINO)DIPHENYLMETHANE

Bis[4-(dimethylamino)phenyl]methane

N,N,N',N'-tetramethyl-4,4'-methylenedianiline

4,4'-METHANEDIYLBIS(N,N-DIMETHYLANILINE)

4,4'-BIS(DIMETHYLAMINO)DIPHENYL METHANE

Michler's hydride

4,4-METHYLENEBIS(N,N'-DIMETHYLANILINE)

4,4'-BIS(DIMETHYLAMINO)DIPHENYLMETHANE

MFCD00008317

4,4 -METHYLENEBIS(N,N-DIMETHYLANILINE)

BENZENAMINE,4,4'-METHYLENEBIS[N,N-DIMETHYL-

EINECS 202-959-2

4,4'-METHYLENE-BIS-(N,N-DIMETHYLANILINE)

Michler's base

BIS-(4-DIMETHYLAMINOPHENYL)-METHAN

bazemichlerova

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