CAS 107133-36-8|Perindopril erbumine
Introduction：Basic information about CAS 107133-36-8|Perindopril erbumine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Perindopril erbumine | ||
|---|---|---|---|
| CAS Number | 107133-36-8 | Molecular Weight | 441.605 |
| Density | 1.15 g/cm3 | Boiling Point | 537.4ºC at 760mmHg |
| Molecular Formula | C23H43N3O5 | Melting Point | 126-128ºC |
| MSDS | ChineseUSA | Flash Point | 278.8ºC |
Names
| Name | perindopril erbumine |
|---|---|
| Synonym | More Synonyms |
Perindopril erbumine BiologicalActivity
| Description | Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.Target: ACEPerindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Cardiovascular Disease |
| References | [1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4. [2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3. |
Chemical & Physical Properties
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 537.4ºC at 760mmHg |
| Melting Point | 126-128ºC |
| Molecular Formula | C23H43N3O5 |
| Molecular Weight | 441.605 |
| Flash Point | 278.8ºC |
| Exact Mass | 441.320282 |
| PSA | 121.96000 |
| LogP | 3.71330 |
| InChIKey | IYNMDWMQHSMDDE-MHXJNQAMSA-N |
| SMILES | CC(C)(C)N.CCCC(NC(C)C(=O)N1C(C(=O)O)CC2CCCCC21)C(=O)OCC |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: soluble10mg/mL, clear |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | NL5999600 |
Articles41
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Synonyms
| Aceon |
| S 9490-3 |
| PrestariuM |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
| (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
| acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1) |
| McN-A 2833-109 |
| McN-A-2833-109 |
| Perinodpril ErbiMune |
| ButylaMiniperindopril |
| Perindoril |
| Perindopril erbumine |
| MFCD02313824 |
| Perindopril tert-butylamine |
| (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1) |
| S-9490-3 |
| Perindopril t-Butylamine Salt |
| (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1) |
| Procaptan |
| Unii-1964X464oj |
| Coversyl |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1) |
| (2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1) |
| Perinodopril |
| Coversum |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) |
| Perindopril t-Butylamine |
