CAS 60-27-5|Creatinine
| Common Name | Creatinine | ||
|---|---|---|---|
| CAS Number | 60-27-5 | Molecular Weight | 113.118 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 184.3±23.0 °C at 760 mmHg |
| Molecular Formula | C4H7N3O | Melting Point | 295 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 65.3±22.6 °C |
Names
| Name | creatinine |
|---|---|
| Synonym | More Synonyms |
Creatinine BiologicalActivity
| Description | Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.Target: OthersCreatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. During the reaction, creatine and phosphocreatine are catalyzed by creatine kinase, and a spontaneous conversion to creatinine may occur [1]. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function [2]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Alkaloid |
| Target | Human Endogenous Metabolite |
| References | [1]. Allen, P.J., Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value. Neurosci Biobehav Rev, 2012. 36(5): p. 1442-62. [2]. Levey, A.S., et al., Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med, 2006. 145(4): p. 247-54. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 184.3±23.0 °C at 760 mmHg |
| Melting Point | 295 °C (dec.)(lit.) |
| Molecular Formula | C4H7N3O |
| Molecular Weight | 113.118 |
| Flash Point | 65.3±22.6 °C |
| Exact Mass | 113.058914 |
| PSA | 58.69000 |
| LogP | -1.68 |
| Vapour Pressure | 0.2±0.8 mmHg at 25°C |
| Index of Refraction | 1.651 |
| InChIKey | DDRJAANPRJIHGJ-UHFFFAOYSA-N |
| SMILES | CN1CC(=O)N=C1N |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | SOLUBLE |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45-S24/25 |
| RIDADR | UN 1789 8/PG 3 |
| WGK Germany | 3 |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles1683
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Synonyms
| Creatinine,heated |
| Creatinine |
| 1-Methylglycocyamidine |
| 4H-Imidazol-4-one,2-amino-1,5-dihydro-1-methyl |
| 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one |
| [3H]-Creatinine |
| 2-amino-1-methylimidazolin-4-one |
| 2-amino-3-methyl-4H-imidazol-5-one |
| 2-Amino-1-methyl-1,5-dihydroimidazol-4-one |
| 1-methyl-2-amino-1,5-dihydroimidazol-4-one |
| EINECS 200-466-7 |
| MFCD00059730 |
| 1-Methylhydantoin-2-imide |
| 2-Amino-1-methyl-1,5-dihydro-4H-imidazol-4-one |
| [14C]-Creatinine |
| 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl- |
| 2-imino-1-methylimidazolidin-4-one |
| 2-Imino-N-methylhydantoin |
