CAS 100648-13-3|Triclabendazole sulfoxide
| Common Name | Triclabendazole sulfoxide | ||
|---|---|---|---|
| CAS Number | 100648-13-3 | Molecular Weight | 375.65700 |
| Density | 1.69 | Boiling Point | 547.6ºC at 760 mmHg |
| Molecular Formula | C14H9Cl3N2O2S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 285ºC |
Names
| Name | 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole |
|---|---|
| Synonym | More Synonyms |
Triclabendazole sulfoxide BiologicalActivity
| Description | Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>BCRP |
| References | [1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43. [2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10. |
Chemical & Physical Properties
| Density | 1.69 |
|---|---|
| Boiling Point | 547.6ºC at 760 mmHg |
| Molecular Formula | C14H9Cl3N2O2S |
| Molecular Weight | 375.65700 |
| Flash Point | 285ºC |
| Exact Mass | 373.94500 |
| PSA | 74.19000 |
| LogP | 5.91850 |
| Vapour Pressure | 4.81E-12mmHg at 25°C |
| Index of Refraction | 1.749 |
| InChIKey | GABQPFWIQFRJSE-UHFFFAOYSA-N |
| SMILES | CS(=O)c1nc2cc(Oc3cccc(Cl)c3Cl)c(Cl)cc2[nH]1 |
| Storage condition | 2-8°C |
Safety Information
| Hazard Statements | H413 |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles21
More Articles| Fasciola hepatica: disruption of the vitelline cells in vitro by the sulphoxide metabolite of triclabendazole. Parasitol. Res. 82(4) , 333-9, (1996) The effects of the active sulphoxide metabolite of the fasciolicide triclabendazole (Fasinex, Ciba-Geigy) on the vitelline cells of Fasciola hepatica were determined in vitro by transmission electron ... | |
| Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep. Exp. Parasitol. 136 , 14-9, (2014) The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemic presence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered fr... | |
| Fasciola gigantica: tegumental surface alterations following treatment in vitro with the sulphoxide metabolite of triclabendazole. Parasitol. Res. 88(4) , 315-25, (2002) The effect of the active sulphoxide metabolite of the fasciolicide triclabendazole on the surface morphology of the tropical liver fluke, Fasciola gigantica, was determined in vitro by scanning electr... |
Synonyms
| Tcbz-SX |
| Triclabendazole sulfoxide |
| 1H-Benzimidazole,6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl) |
| 5-chloro-6-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole |
| triclabendazole sulphoxide |
