Introduction：Basic information about CAS 109425-51-6|Fmoc-His(Trt)-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fmoc-His(Trt)-OH |
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| CAS Number | 109425-51-6 | Molecular Weight | 619.708 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 811.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C40H33N3O4 | Melting Point | 150-155 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 444.7±34.3 °C |
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Names
| Name | N-Fmoc-N'-trityl-L-histidine |
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| Synonym | More Synonyms |
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Fmoc-His(Trt)-OH BiologicalActivity
| Description | Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 811.7±65.0 °C at 760 mmHg |
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| Melting Point | 150-155 °C(lit.) |
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| Molecular Formula | C40H33N3O4 |
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| Molecular Weight | 619.708 |
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| Flash Point | 444.7±34.3 °C |
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| Exact Mass | 619.247131 |
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| PSA | 93.45000 |
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| LogP | 8.03 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.657 |
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| InChIKey | XXMYDXUIZKNHDT-QNGWXLTQSA-N |
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| SMILES | O=C(NC(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C(=O)O)OCC1c2ccccc2-c2ccccc21 |
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| Storage condition | 2-8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Articles2
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Synonyms
| MFCD00043332 |
| N-Fmoc-N'-Trityl-L-Histidine |
| N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine |
| N-alpha-FMOC-N-Trityl-L-histidine |
| EINECS 439-640-4 |
| Nα-Fmoc-N(im)-trityl-L-histidine |
| Na-Fmoc-Nim-trityl-L-histidine |
| Fmoc-His(Trt)-OH |
| Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine |
| N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine, |
| (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid |
| L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)- |
| Nα-Fmoc-τ-trityl-L-histidine |
| Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine |
