CAS 7631-95-0|Sodium molybdate

CHEMICAL IDENTIFICATION

RTECS NUMBER :

QA5075000

CHEMICAL NAME :

Molybdic acid, disodium salt

CAS REGISTRY NUMBER :

7631-95-0

LAST UPDATED :

199806

DATA ITEMS CITED :

36

MOLECULAR FORMULA :

Mo-O4.2Na

MOLECULAR WEIGHT :

205.92

WISWESSER LINE NOTATION :

NA2 MO-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2080 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

576 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

303 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

570 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

917 mg/kg

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18200 mg/kg/13W-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - domestic

DOSE/DURATION :

484 mg/kg/21W-I

TOXIC EFFECTS :

Blood - other changes Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intratesticular

DOSE :

16474 ug/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TEST SYSTEM :

Yeast - Saccharomyces cerevisiae

DOSE/DURATION :

80 mmol/L

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,21,1986 *** REVIEWS *** ACGIH TLV-TWA 5 mg(Mo)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg(Mo)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,173,1971 OSHA PEL (Gen Indu):8H TWA 5 mg(Mo)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 mg(Mo)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 mg(Mo)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 mg(Mo)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg(Mo)/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg(Mo)/m3 JAN 1993 OEL-DENMARK:TWA 5 mg(Mo)/m3 JAN 1993 OEL-FINLAND:TWA 5 mg(Mo)/m3 JAN 1993 OEL-FRANCE:TWA 5 mg(Mo)/m3;STEL 10 mg(Mo)/m3 JAN 1993 OEL-GERMANY:TWA 5 mg(Mo)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg(Mo)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg(Mo)/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg(Mo)/m3 JAN 1993 OEL-TURKEY:TWA 5 mg(Mo)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg(Mo)/m3;STEL 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81120 No. of Facilities: 1540 (estimated) No. of Industries: 35 No. of Occupations: 33 No. of Employees: 10443 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81120 No. of Facilities: 2082 (estimated) No. of Industries: 55 No. of Occupations: 46 No. of Employees: 33075 (estimated) No. of Female Employees: 6787 (estimated)

Biochem. Biophys. Res. Commun. 464 , 275-80, (2015)

Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the ...

J. Proteomics 114 , 48-60, (2015)

The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tu...

Oncotarget 6 , 14522-36, (2015)

14-3-3 proteins play a pivotal role in controlling cell proliferation and survival, two commonly dysregulated hallmarks of cancers. 14-3-3 protein expression is enhanced in many human cancers and corr...