CAS 41743-73-1|Irisflorentin

Introduction：Basic information about CAS 41743-73-1|Irisflorentin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameIrisflorentin
CAS Number41743-73-1Molecular Weight386.352
Density1.3±0.1 g/cm3Boiling Point569.1±50.0 °C at 760 mmHg
Molecular FormulaC20H18O8Melting Point169 °C
MSDS/Flash Point250.5±30.2 °C

Names

Name9-methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
SynonymMore Synonyms

Irisflorentin BiologicalActivity

DescriptionIrisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1].
Related CatalogSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/Immunology
In VitroIrisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM[1]. Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation[1]. RT-PCR[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS mRNA expression. Suppressed the production of TNF-α, IL-1β and IL-6. Western Blot Analysis[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS protein levels. Suppressed LPS-induced p38 and ERK1/2 phosphorylation, but slightly affected JNK phosphorylation.
References

[1]. Gao Y, et al. Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages. Exp Biol Med (Maywood). 2014 Aug;239(8):1018-1024.

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point569.1±50.0 °C at 760 mmHg
Melting Point169 °C
Molecular FormulaC20H18O8
Molecular Weight386.352
Flash Point250.5±30.2 °C
Exact Mass386.100159
PSA85.59000
LogP3.19
Vapour Pressure0.0±1.6 mmHg at 25°C
Index of Refraction1.593
InChIKeyRISXUTCDCPHJFQ-UHFFFAOYSA-N
SMILESCOc1cc(-c2coc3cc4c(c(OC)c3c2=O)OCO4)cc(OC)c1OC
Storage condition2-8°C

Safety Information

Safety Phrases24/25
RIDADRNONH for all modes of transport
HS Code2932999099

Customs

HS Code2932999099
Summary2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Irisflorentin
3',4',5',5-tetramethoxy-6,7-methylenedioxyisoflavone
irisflorentine
9-methoxy-7-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one
8H-1,3-Dioxolo[4,5-g][1]benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)-
N1426
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo(4,5-g)(1)benzopyran-8-one
5,3',4',5'-Tetramethoxy-6,7-methylenedioxyisoflavone
8H-1,3-Dioxolo(4,5-g)(1)benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)-
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