CAS 69884-00-0|Pseudoginsenoside F11

Introduction：Basic information about CAS 69884-00-0|Pseudoginsenoside F11, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pseudoginsenoside F11 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Pseudoginsenoside F11
CAS Number	69884-00-0	Molecular Weight	801.013
Density	1.3±0.1 g/cm3	Boiling Point	885.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₇₂O₁₄	Melting Point	/
MSDS	ChineseUSA	Flash Point	489.2±34.3 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	(3b,6a,12b,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
Synonym	More Synonyms

Pseudoginsenoside F11 BiologicalActivity

Description	Pseudoginsenoside-F11 (PF11), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice. IC50 value: Inhibition of diprenorphine binding with an IC50 of 6.1 μM Target:In vitro: Biochemical experiments revealed that PF11 could inhibit diprenorphine (DIP) binding with an IC50 of 6.1 μM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-μ cells [2].In vivo: One in vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with Pseudoginsenoside F11 reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage [1]. We tested the effects of Pseudoginsenoside F11 on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, Pseudoginsenoside F11 antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine [3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides
References	[1]. Wang H, et al. The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo. Scientific Reports [2014, 4:4986] [2]. Li Zhu, et al. Pseudoginsenoside-F11 attenuates morphine-induced signalling in Chinese hamster ovary-μ cells. Neuroreport, 25 May 2001 - Volume 12 - Issue 7 - pp 1453-1456 [3]. Yue Hao, et al. Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice. Pharmacology Biochemistry and Behavior Volume 86, Issue 4, April 2007, Pages 660–666

Description

Pseudoginsenoside-F11 (PF11), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice. IC50 value: Inhibition of diprenorphine binding with an IC50 of 6.1 μM Target:In vitro: Biochemical experiments revealed that PF11 could inhibit diprenorphine (DIP) binding with an IC50 of 6.1 μM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-μ cells [2].In vivo: One in vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with Pseudoginsenoside F11 reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage [1]. We tested the effects of Pseudoginsenoside F11 on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, Pseudoginsenoside F11 antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine [3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides

References

[1]. Wang H, et al. The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo. Scientific Reports [2014, 4:4986]

[2]. Li Zhu, et al. Pseudoginsenoside-F11 attenuates morphine-induced signalling in Chinese hamster ovary-μ cells. Neuroreport, 25 May 2001 - Volume 12 - Issue 7 - pp 1453-1456

[3]. Yue Hao, et al. Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice. Pharmacology Biochemistry and Behavior Volume 86, Issue 4, April 2007, Pages 660–666

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	885.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₇₂O₁₄
Molecular Weight	801.013
Flash Point	489.2±34.3 °C
Exact Mass	800.492188
PSA	228.22000
LogP	5.27
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.599
InChIKey	JBGYSAVRIDZNKA-NOYKOGHLSA-N
SMILES	CC1OC(OC2C(OC3CC4(C)C(CC(O)C5C(C6(C)CCC(C(C)(C)O)O6)CCC54C)C4(C)CCC(O)C(C)(C)C34)OC(CO)C(O)C2O)C(O)C(O)C1O
Storage condition	2-8°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29389090

Synonyms

(3β,6α,12β,24R)-3,12,25-Trihydroxy-20,24-epoxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-mannopyranoside

pseudo-ginsenoside-Fll

GINSENOSIDE A1

β-D-Mannopyranoside, (3β,6α,12β,24R)-20,24-epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-

(3b,6a,12b,24R)-20,24-Epoxy-3,12,25

MFCD00803938

PSEUDOGINSENOSIDE

Pseuginsenoside F11

(24R)-Pseudoginsenoside F11

24(S)-pseudo-ginsenoside-F11

Pseudoginsenoside FII

Pseudoginsenoside-F11

Pseuginsensoside F11

Pseudoginsenoside F11

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