Introduction：Basic information about CAS 2424-92-2|Icosanedioic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Icosanedioic acid |
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| CAS Number | 2424-92-2 | Molecular Weight | 342.513 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 504.1±23.0 °C at 760 mmHg |
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| Molecular Formula | C20H38O4 | Melting Point | 127ºC |
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| MSDS | / | Flash Point | 272.8±19.1 °C |
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Names
| Name | eicosanedioic acid |
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| Synonym | More Synonyms |
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Icosanedioic acid BiologicalActivity
| Description | Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 504.1±23.0 °C at 760 mmHg |
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| Melting Point | 127ºC |
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| Molecular Formula | C20H38O4 |
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| Molecular Weight | 342.513 |
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| Flash Point | 272.8±19.1 °C |
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| Exact Mass | 342.277008 |
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| PSA | 74.60000 |
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| LogP | 7.18 |
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| Appearance of Characters | Powder |
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| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
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| Index of Refraction | 1.474 |
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| InChIKey | JJOJFIHJIRWASH-UHFFFAOYSA-N |
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| SMILES | O=C(O)CCCCCCCCCCCCCCCCCCC(=O)O |
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| Water Solubility | Slightly soluble in water. |
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Safety Information
| Safety Phrases | S22-S24/25 |
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| HS Code | 2917190090 |
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Customs
| HS Code | 2917190090 |
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| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| eicosadioic acid |
| Icosanedioic acid |
| 1,18-Octadecanedicarboxylic acid |
| eicosa-1,20-dioic acid |
| eicosane diacid |
| 1,20-icosanedioic acid |
| Eicossandioic acid |
| eicosandioic acid |
| Eicosanedioic acid |
| MFCD00059627 |
| octadecane-1,18-dicarboxylic acid |
