Introduction：Basic information about CAS 104-29-0|Chlorphenesin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chlorphenesin |
|---|
| CAS Number | 104-29-0 | Molecular Weight | 202.635 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 369.5±27.0 °C at 760 mmHg |
|---|
| Molecular Formula | C9H11ClO3 | Melting Point | 77-79°C |
|---|
| MSDS | / | Flash Point | 177.2±23.7 °C |
|---|
Names
| Name | chlorphenesin |
|---|
| Synonym | More Synonyms |
|---|
Chlorphenesin BiologicalActivity
| Description | Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics[1]. |
|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
|---|
| In Vitro | Chlorphenesin (0.01, 0.1, 0.3%; 30-min exposure) significantly reduces the activity of the Akt pathway in a dose-dependent manner in human meibomian gland epithelial cells (HMGECs)[2]. Chlorphenesin (0.1, 0.3%; 24 hours) induces immortalized HMGECs (IHMGECs) rounding, atrophy, poor adherence, detachme and significantly reduces the number of IHMGECs[2]. |
|---|
| References | [1]. H Y Whang, et al. Chlorphenesin: an antigen-associated immunosuppressant. Infect Immun. 1970 Jul;2(1):60-4. [2]. Jingyi Wang, et al. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Exp Eye Res. 2020 Jul;196:108057. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 369.5±27.0 °C at 760 mmHg |
|---|
| Melting Point | 77-79°C |
|---|
| Molecular Formula | C9H11ClO3 |
|---|
| Molecular Weight | 202.635 |
|---|
| Flash Point | 177.2±23.7 °C |
|---|
| Exact Mass | 202.039673 |
|---|
| PSA | 49.69000 |
|---|
| LogP | 1.43 |
|---|
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
|---|
| Index of Refraction | 1.565 |
|---|
| InChIKey | MXOAEAUPQDYUQM-UHFFFAOYSA-N |
|---|
| SMILES | OCC(O)COc1ccc(Cl)cc1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TY4260000
- CHEMICAL NAME :
- 1,2-Propanediol, 3-(p-chlorophenoxy)-
- CAS REGISTRY NUMBER :
- 104-29-0
- BEILSTEIN REFERENCE NO. :
- 2210845
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C9-H11-Cl-O3
- MOLECULAR WEIGHT :
- 202.65
- WISWESSER LINE NOTATION :
- Q1YQ1OR DG
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 911 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,470,1948
|
Safety Information
| Hazard Codes | Xn |
|---|
| Risk Phrases | R20/21/22 |
|---|
| Safety Phrases | S26-S36 |
|---|
| HS Code | 2909499000 |
|---|
Customs
| HS Code | 2909499000 |
|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
|---|
Synonyms
| Gecophen |
| Adermykon |
| Demykon |
| EINECS 203-192-6 |
| 3-(4-Chlorophenoxy)-1,2-propanediol |
| 3-(4-chlorophenoxy)propane-1,2-diol |
| Chlorphenesinum |
| 3-(p-Chlorophenoxy)propane-1,2-diol |
| Mycil |
| 1,2-Propanediol, 3- (p-chlorophenoxy)- |
| p-chlorophenyl a-glyceryl ether |
| Chlorphenesine |
| Clorfenesina |
| MFCD00021990 |
| Chlorphenesin |
| 1,2-Propanediol, 3-(4-chlorophenoxy)- |
| Chlorophenesin |
