CAS 7664-39-3|HYDROFLUORIC ACID

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MW7875000

CHEMICAL NAME :

Hydrofluoric acid

CAS REGISTRY NUMBER :

7664-39-3

LAST UPDATED :

199712

DATA ITEMS CITED :

54

MOLECULAR FORMULA :

F-H

MOLECULAR WEIGHT :

20.01

WISWESSER LINE NOTATION :

H F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Human

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

100 mg/m3/1M

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - cough

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

143 mg/kg

TOXIC EFFECTS :

Cardiac - arrhythmias (including changes in conduction) Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

50 ppm/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1276 ppm/1H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

342 ppm/1H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

1774 ppm/1H

TOXIC EFFECTS :

Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - other changes

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

260 mg/m3/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

4327 ppm/15M

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

112 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 ug/m3/24H/22W-C

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

252 ug/m3/6H/17W-I

TOXIC EFFECTS :

Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

470 ug/m3/4H

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

4980 ug/m3/4H

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

DNA damage

TYPE OF TEST :

Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :

Rodent - rat

REFERENCE :

CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(1),40,1975 *** REVIEWS *** ACGIH TLV-CL 2.3 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 400,5,1963 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 3 ppm (2 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,131,1971 OSHA PEL (Gen Indu):8H TWA 3 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 ppm (2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (2 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 3 ppm (2.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 3 ppm (2.6 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (1.6 mg/m3) JAN 1993 OEL-FINLAND:STEL 6 ppm;Skin JAN 1993 OEL-FRANCE:STEL 3 ppm (2.5 mg/m3) JAN 1993 OEL-GERMANY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993 OEL-JAPAN:TWA 3 ppm (25 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 3 ppm (0.1 mg/m3);STEL 0.5 mg/m3 JAN 1993 OEL-SWEDEN:STEL 2 ppm (1.7 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg/m3);STEL 3.6 ppm (3 mg/m3) JAN 1993 OEL-TURKEY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 3 ppm (2.5 mg/m3);STEL 6 ppm (5 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDROGEN FLUORIDE-air:10H TWA 3 ppm;STEL 6 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38550 No. of Facilities: 6590 (estimated) No. of Industries: 97 No. of Occupations: 68 No. of Employees: 68886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38550 No. of Facilities: 11332 (estimated) No. of Industries: 96 No. of Occupations: 89 No. of Employees: 189051 (estimated) No. of Female Employees: 68792 (estimated)

Invest. Ophthalmol. Vis. Sci. 55(12) , 8153-62, (2014)

Vitreous liquefaction and subsequent posterior vitreous detachment can lead to several sight-threatening diseases, including retinal detachment, macular hole and macular traction syndrome, nuclear cat...

J. Med. Microbiol. 63(Pt 11) , 1474-83, (2014)

Arbidol (ARB) is an antiviral drug that has broad-spectrum activity against a number of viral infections. To date, there are no specific data regarding its effects against a herpesvirus. Here, the in ...

PLoS ONE 10(4) , e0124242, (2015)

The autonomic nervous system (ANS) plays an important role in regulating the metabolic homeostasis and controlling immune function. ANS alterations can be detected by reduced heart rate variability (H...