CAS 56038-13-2|Sucralose

Introduction：Basic information about CAS 56038-13-2|Sucralose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sucralose BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles50
8. Synonyms

Common Name	Sucralose
CAS Number	56038-13-2	Molecular Weight	397.634
Density	1.7±0.1 g/cm3	Boiling Point	669.4±55.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₉Cl₃O₈	Melting Point	125.5ºC
MSDS	ChineseUSA	Flash Point	358.7±31.5 °C

Names

Name	sucralose
Synonym	More Synonyms

Sucralose BiologicalActivity

Description	Sucralose is an intense organochlorine artificial sweetener.
Related Catalog	Signaling Pathways >>Others >>OthersNatural Products >>Saccharides and GlycosidesResearch Areas >>Cancer
In Vivo	The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000 (p≤0.01), and 16,000 ppm (p≤0.01), with a significant dose-related relationship (p≤0.01). Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues[1].
Animal Admin	Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].
References	[1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	669.4±55.0 °C at 760 mmHg
Melting Point	125.5ºC
Molecular Formula	C₁₂H₁₉Cl₃O₈
Molecular Weight	397.634
Flash Point	358.7±31.5 °C
Exact Mass	396.014557
PSA	128.84000
LogP	0.68
Vapour Pressure	0.0±4.6 mmHg at 25°C
Index of Refraction	1.604
InChIKey	BAQAVOSOZGMPRM-QBMZZYIRSA-N
SMILES	OCC1OC(OC2(CCl)OC(CCl)C(O)C2O)C(O)C(O)C1Cl
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW5440140

CHEMICAL NAME :: alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-

CAS REGISTRY NUMBER :: 56038-13-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H19-Cl3-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >16 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TBSCDB Trends in Biochemical Sciences. (Elsevier Science Publishing Co., Inc., 655 Avenue of the Americas, New York, NY 10010) V.1- 1976- Volume(issue)/page/year: 3,61,1978

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	LW5440140
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles50

A novel ion-exclusion chromatography–mass spectrometry method to measure concentrations and cycling rates of carbohydrates and amino sugars in freshwaters

J. Chromatogr. A. 1365 , 115-23, (2014)

• Novel HPLC–MS method for carbohydrate and amino sugar analysis in freshwaters. • Rapid and efficient determination without derivatization or sample pre-concentration. • Implementation of stable isot...

Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry.

Anal. Bioanal. Chem 407(5) , 1505-12, (2015)

The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebau...

Identification, quantification, and sensory characterization of steviol glycosides from differently processed Stevia rebaudiana commercial extracts.

J. Agric. Food Chem. 62(49) , 11797-804, (2014)

Stevia rebaudiana is known for its sweet-tasting ent-kaurene diterpenoid glycosides. Several manufacturing strategies are currently employed to obtain Stevia sweeteners with the lowest possible off-fl...

Synonyms

(2R,3R,4R,5R,6R)-2-{[(2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydro-2-furanyl]oxy}-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol

1',4,6'-Trichlorogalactosucrose

1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside

a-D-galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-

trichlorosucrose

(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol

MFCD03648615

1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-a-D-galactopyranoside

Sucralose

EINECS 259-952-2

1,6-Dichlor-1,6-dideoxy-β-D-fructofuranosyl-4-chlor-4-deoxy-α-D-galactopyranoside

4,1',6'-Trichloro-4,1',6'-trideoxygalacto-sucrose

1,6-Dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside

splenda

α-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-

UNII-96K6UQ3ZD4

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