CAS 22425-82-7|methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamet

Introduction：Basic information about CAS 22425-82-7|methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamet, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Namemethyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
CAS Number22425-82-7Molecular Weight486.72600
Density1.11g/cm3Boiling Point541.9ºC at 760mmHg
Molecular FormulaC31H50O4Melting Point/
MSDS/Flash Point163.1ºC

Names

Namemethyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
SynonymMore Synonyms

BiologicalActivity

DescriptionMethyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
In VivoMethyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1]. Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1]. Animal Model: Wistar male rats (300-320 g)[1] Dosage: 20-60 mg/kg Administration: Intraperitoneal injection; once Result: Showed significant, dose-response vasodepressor effect and sinus bradicardia. Antagonized β-Adrenergic. Showed antidysrhythmic activity.
References

[1]. Somova LI, et al. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004 Feb;11(2-3):121-9.

Chemical & Physical Properties

Density1.11g/cm3
Boiling Point541.9ºC at 760mmHg
Molecular FormulaC31H50O4
Molecular Weight486.72600
Flash Point163.1ºC
Exact Mass486.37100
PSA66.76000
LogP6.29280
Vapour Pressure5.29E-14mmHg at 25°C
Index of Refraction1.552
InChIKeyOTDUGESKRJHFHR-UHFFFAOYSA-N
SMILESCOC(=O)C12CCC(C)(C)CC1C1=CCC3C4(C)CC(O)C(O)C(C)(C)C4CCC3(C)C1(C)CC2

Synonyms

Crategolic acid methyl ester
Methyl maslinate
Maslinic acid methyl ester
2alpha,3beta-Dihydroxyolean-12-en-28-oic acid methyl ester
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