CAS 81-61-8|Quinalizarin
| Common Name | Quinalizarin | ||
|---|---|---|---|
| CAS Number | 81-61-8 | Molecular Weight | 272.210 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Molecular Formula | C14H8O6 | Melting Point | 99 °C |
| MSDS | ChineseUSA | Flash Point | 280.6±25.2 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | quinalizarin |
|---|---|
| Synonym | More Synonyms |
Quinalizarin BiologicalActivity
| Description | Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an Ki of ~50 nM and an IC50 of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Casein KinaseSignaling Pathways >>Stem Cell/Wnt >>Casein Kinase |
| Target | CK2:~50 nM (Ki) CK2:110 nM (IC50) |
| References | [1]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15. |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Melting Point | 99 °C |
| Molecular Formula | C14H8O6 |
| Molecular Weight | 272.210 |
| Flash Point | 280.6±25.2 °C |
| Exact Mass | 272.032074 |
| PSA | 115.06000 |
| LogP | 5.18 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.815 |
| InChIKey | VBHKTXLEJZIDJF-UHFFFAOYSA-N |
| SMILES | O=C1c2ccc(O)c(O)c2C(=O)c2c(O)ccc(O)c21 |
| Storage condition | room temp |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 50 ug/plate
- REFERENCE :
- BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 50 ug/plate
- REFERENCE :
- BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| Hazard Codes | Xn,N |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | UN 3077 9 / PGIII |
Articles8
More Articles| Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127. Biochim. Biophys. Acta 1853 , 1693-701, (2015) In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subuni... | |
| A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression. Cell. Mol. Life Sci. 71(21) , 4243-58, (2014) Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific pep... | |
| Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression. Int. J. Oncol. 48 , 1073-84, (2016) The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. Human NPC cell lines ... |
Synonyms
| 1,2,5,8-tetrahydroxy-9,10-anthracenedione |
| Alizarinbordeaux |
| 9,10-Anthracenedione, 1,2,5,8-tetrahydroxy- |
| MFCD00001205 |
| 9,10-Anthracenedione,1,2,5,8-tetrahydroxy |
| Alizarine Bordeaux B |
| 1,2,5,8-Tetrahydroxy-9,10-anthraquinone |
| Mordant Violet 26 |
| Khinalizarin |
| Alizarine Bordeaux |
| C.I. Mordant Violet 26 |
| Alizarin bordeaux B |
| 1,2,5,8-tetrahydroxyanthracene-9,10-dione |
| Quinalizarin |
| 1,2,5,8-tetrahydroxyanthraquinone |
| EINECS 201-366-6 |
