CAS 10331-57-4|Niclofolan
Introduction：Basic information about CAS 10331-57-4|Niclofolan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Niclofolan | ||
|---|---|---|---|
| CAS Number | 10331-57-4 | Molecular Weight | 345.092 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 424.9±45.0 °C at 760 mmHg |
| Molecular Formula | C12H6Cl2N2O6 | Melting Point | / |
| MSDS | / | Flash Point | 210.8±28.7 °C |
Names
| Name | 4-chloro-2-(5-chloro-2-hydroxy-3-nitrophenyl)-6-nitrophenol |
|---|---|
| Synonym | More Synonyms |
Niclofolan BiologicalActivity
| Description | Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| In Vitro | Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions[3]. Cell Viability Assay[3] Cell Line: Gyrodactylus sp. (parasite) Concentration: 0.12 mg/mL Incubation Time: 60 min Result: Reduced the number of live Gyrodactylus sp. By 100%. |
| In Vivo | Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2]. Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4]. Animal Model: fasciola hepatica infected sheep[2] Dosage: 2 mg/kg Administration: Intramuscular injection Result: Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection. Animal Model: Rats infected with P.iloktsuenesis[4] Dosage: 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times. Administration: Oral gavage Result: Reduced the worms in rats. |
| References | [1]. T Eckhardt, Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct; 81(4):795-8. [2]. B H Ali, T Hassan, et al. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. [3]. Santamarina M. T., et al. Anthelmintic treatment against Gyrodactylus sp. infecting rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 1991 10(1): 39-43. [4]. Rim H J, et al. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. The Korean Journal of Parasitology, 1976, 14(2): 140-146. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 424.9±45.0 °C at 760 mmHg |
| Molecular Formula | C12H6Cl2N2O6 |
| Molecular Weight | 345.092 |
| Flash Point | 210.8±28.7 °C |
| Exact Mass | 343.960297 |
| PSA | 132.10000 |
| LogP | 3.97 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.706 |
| InChIKey | XULACPAEUUWKFX-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])c1cc(Cl)cc(-c2cc(Cl)cc([N+](=O)[O-])c2O)c1O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971
Safety Information
| Hazard Codes | C |
|---|---|
| HS Code | 2907299090 |
Customs
| HS Code | 2907299090 |
|---|---|
| Summary | 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
Synonyms
| Bayer 9015 |
| EINECS 233-720-0 |
| ME 3625 |
| Bilevon M |
| 5,5'-dichloro-3,3'-dinitro-2,2'-biphenyldiol |
| 5,5'-dichloro-3,3'-dinitrobiphenyl-2,2'-diol |
| Niclofolanum [INN-Latin] |
| Niclofolano [INN-Spanish] |
| 5,5'-Dichloro-3,3'-dinitro-[1,1'-biphenyl]-2,2'-diol |
| Niclofolan |
| BAY 9015 |
| Menichlopholan |
| 2,2'-Dihydroxy-3,3'-dinitro-5,5'-dichlor-diphenyl |
