CAS 37682-72-7|BDBM32804
| Common Name | BDBM32804 | ||
|---|---|---|---|
| CAS Number | 37682-72-7 | Molecular Weight | 677.623 |
| Density | / | Boiling Point | / |
| Molecular Formula | C27H46Cl2N10O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Antipain dihydrochloride |
|---|---|
| Synonym | More Synonyms |
BDBM32804 BiologicalActivity
| Description | Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Metabolic Disease |
| In Vivo | The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4]. Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5]. |
| References | [1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53. [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6. [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76. [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626. [5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757. |
Chemical & Physical Properties
| Molecular Formula | C27H46Cl2N10O6 |
|---|---|
| Molecular Weight | 677.623 |
| Exact Mass | 676.297913 |
| PSA | 277.50000 |
| LogP | 4.25060 |
| InChIKey | RJRYYNKRPUWLRZ-UHFFFAOYSA-N |
| SMILES | CC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)NC(Cc1ccccc1)C(=O)O)C(=O)NC(C=O)CCCN=C(N)N.Cl |
| Storage condition | 20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| RTECS | YV9350800 |
Articles10
More Articles| Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells. Biochem. Pharmacol. 49 , 1236-47, (2010) Usher syndrome is the major cause of deaf/blindness in the world. It is a genetic heterogeneous disorder, with nine genes already identified as causative for the disease. We noted expression of all kn... | |
| Preparation of extracts from plants. Meth. Enzymol. 182 , 174-193, (1990) | |
| Maintaining protein stability. Meth. Enzymol. 182 , 83-89, (1990) |
Synonyms
| L-Valinamide, N-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-N-(diaminomethylene)-L-ornithyl-N-[4-[(diaminomethylene)amino]-1-formylbutyl]-, hydrochloride (1:2) |
| N-[(1-Carboxy-2-phenylethyl)carbamoyl]-L-arginyl-N-(5-carbamimidamido-1-oxopentan-2-yl)-L-valinamide dihydrochloride |
| MFCD00135957 |
| antipain, dihydrochloride |
| N-[(1-Carboxy-2-phenylethyl)carbamoyl]-N-(diaminomethylene)-L-ornithyl-N-{5-[(diaminomethylene)amino]-1-oxo-2-pentanyl}-L-valinamide dihydrochloride |
| L-valinamide, N-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, hydrochloride (1:2) |
| Antipain |
