CAS 220805-22-1|NG,NG-Dimethylarginine Dihydrochloride
| Common Name | NG,NG-Dimethylarginine Dihydrochloride | ||
|---|---|---|---|
| CAS Number | 220805-22-1 | Molecular Weight | 275.18 |
| Density | / | Boiling Point | 427.5ºC at 760 mmHg |
| Molecular Formula | C8H20Cl2N4O2 | Melting Point | 202-204OºC |
| MSDS | ChineseUSA | Flash Point | 212.4ºC |
Names
| Name | NG,NG-Dimethylarginine Dihydrochloride |
|---|---|
| Synonym | More Synonyms |
NG,NG-Dimethylarginine Dihydrochloride BiologicalActivity
| Description | Asymmetric dimethylarginine dihydrochloride is an endogenous NO synthase inhibitor that reduces NO production, which contributes to endothelial dysfunction and cardiovascular disease[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NO Synthase |
| References | [1]. Latika Sibal, et al. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90. |
Chemical & Physical Properties
| Boiling Point | 427.5ºC at 760 mmHg |
|---|---|
| Melting Point | 202-204OºC |
| Molecular Formula | C8H20Cl2N4O2 |
| Molecular Weight | 275.18 |
| Flash Point | 212.4ºC |
| Exact Mass | 274.096344 |
| PSA | 102.44000 |
| LogP | 2.05940 |
| Vapour Pressure | 1.66E-08mmHg at 25°C |
| InChIKey | SYLNVYJOPZWPJI-ILKKLZGPSA-N |
| SMILES | CN(C)C(N)=NCCCC(N)C(=O)O.Cl.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles60
More Articles| Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J. Biol. Chem. 290 , 16723-43, (2015) Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splic... | |
| PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat. Commun. 6 , 6428, (2015) The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two splic... | |
| Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples. Mol. Med. Report. 12 , 2253-62, (2015) A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interactio... |
Synonyms
| asym-Dimethylarginine ADMA |
| NG,NG-Dimethylarginine dihydrochloride |
| MFCD00270857 |
| (Z)-N-[Amino(dimethylamino)methylene]-L-ornithine dihydrochloride |
| L-Ornithine, N-[amino(dimethylamino)methylene]-, (Z)-, hydrochloride (1:2) |
| NG,NG-DimethylarginineDihydrochloride |
| (2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid,dihydrochloride |
