CAS 75184-71-3|Albendazole sulfone
| Common Name | Albendazole sulfone | ||
|---|---|---|---|
| CAS Number | 75184-71-3 | Molecular Weight | 297.33000 |
| Density | 1.42g/cm3 | Boiling Point | / |
| Molecular Formula | C12H15N3O4S | Melting Point | 290-292ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07, GHS08 | Signal Word | Warning |
Names
| Name | Albendazole sulfone |
|---|---|
| Synonym | More Synonyms |
Albendazole sulfone BiologicalActivity
| Description | Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| References | [1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61. [2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6. |
Chemical & Physical Properties
| Density | 1.42g/cm3 |
|---|---|
| Melting Point | 290-292ºC |
| Molecular Formula | C12H15N3O4S |
| Molecular Weight | 297.33000 |
| Exact Mass | 297.07800 |
| PSA | 109.53000 |
| LogP | 3.07870 |
| Index of Refraction | 1.619 |
| InChIKey | CLSJYOLYMZNKJB-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)c1ccc2nc(NC(=O)OC)[nH]c2c1 |
| Storage condition | -20°C Freezer |
| Water Solubility | Soluble in DMSO, and methanol. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 75 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 75 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H361d |
| Precautionary Statements | P281-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 63-36/38 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| RTECS | DD6520700 |
| HS Code | 29339900 |
Articles2
More Articles| Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014) A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be... | |
| Nickel Oxide Nanoparticle-Deposited Silica Composite Solid-Phase Extraction for Benzimidazole Residue Analysis in Milk and Eggs by Liquid Chromatography-Mass Spectrometry. J. Agric. Food Chem. 64 , 356-63, (2016) A novel nickel oxide nanoparticle-deposited silica (SiO2@NiO) composite was prepared via liquid-phase deposition (LPD) and then employed as a solid-phase extraction (SPE) sorbent. When the SPE was cou... |
Synonyms
| albendazole sulfone |
