CAS 72040-63-2|Biotin-C5-NHS Ester
Introduction：Basic information about CAS 72040-63-2|Biotin-C5-NHS Ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin-C5-NHS Ester | ||
|---|---|---|---|
| CAS Number | 72040-63-2 | Molecular Weight | 454.540 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C20H30N4O6S | Melting Point | 169-171 °C |
| MSDS | USA | Flash Point | / |
Names
| Name | Succinimidyl-6-(biotinamido) Hexanoate |
|---|---|
| Synonym | More Synonyms |
Biotin-C5-NHS Ester BiologicalActivity
| Description | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 169-171 °C |
| Molecular Formula | C20H30N4O6S |
| Molecular Weight | 454.540 |
| Exact Mass | 454.188599 |
| PSA | 159.21000 |
| LogP | -1.62 |
| Index of Refraction | 1.591 |
| InChIKey | UVGHPGOONBRLCX-NJSLBKSFSA-N |
| SMILES | O=C(CCCCC1SCC2NC(=O)NC21)NCCCCCC(=O)ON1C(=O)CCC1=O |
| Storage condition | −20°C |
| Stability | Moisture Sensitive |
| Water Solubility | H2O: ≤2 mg/mL with sonication |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles15
More Articles| Avidin binding of carboxyl-substituted biotin and analogues. Biochemistry 21 , 978-984, (1982) | |
| Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis. J. Cell Biol. 139 , 1523-1531, (1997) Ligation of major histocompatability complex class I (MHC-I) molecules expressed on T cells leads to both growth arrest and apoptosis. The aim of the current study was to investigate the intracellular... | |
| ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev. 15 , 1067-1077, (2001) The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomi... |
Synonyms
| (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate |
| N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
| MFCD00065502 |
| N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
| 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)- |
