Introduction：Basic information about CAS 60784-46-5|elmustine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | elmustine |
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| CAS Number | 60784-46-5 | Molecular Weight | 195.60400 |
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| Density | 1.45g/cm3 | Boiling Point | / |
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| Molecular Formula | C5H10ClN3O3 | Melting Point | 56°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.45g/cm3 |
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| Melting Point | 56°C |
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| Molecular Formula | C5H10ClN3O3 |
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| Molecular Weight | 195.60400 |
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| Exact Mass | 195.04100 |
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| PSA | 82.00000 |
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| LogP | 0.30140 |
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| Index of Refraction | 1.549 |
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| InChIKey | YJZJEQBSODVMTH-UHFFFAOYSA-N |
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| SMILES | O=NN(CCCl)C(=O)NCCO |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YS4986000
- CHEMICAL NAME :
- Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-
- CAS REGISTRY NUMBER :
- 60784-46-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C5-H10-Cl-N3-O3
- MOLECULAR WEIGHT :
- 195.63
- WISWESSER LINE NOTATION :
- Q2MVNNO&2G
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25300 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 64 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 96 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- DNA damage
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Lung
- DOSE/DURATION :
- 1 mg/L/1H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,87,1977
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Synonyms
| Hydroxyethyl CNU |
| CNU-ethanol |
| 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitroso urea |
| N-(2-Hydroxyethyl)-N'-(2-chloroethyl)-N'-nitrosourea |
| N1-(2-hydroxyethyl)-N3-(2-chloroethyl)-N3-nitrosourea |
| Hecnu |
| Elmustine |
| Elmustine [INN] |
| Elmustinum [Latin] |
| Elmustina [Spanish] |
