Introduction：Basic information about CAS 24527-27-3|spiclomazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | spiclomazine |
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| CAS Number | 24527-27-3 | Molecular Weight | 446.03 |
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| Density | 1.42g/cm3 | Boiling Point | 695.3ºC at 760mmHg |
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| Molecular Formula | C22H24ClN3OS2 | Melting Point | / |
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| MSDS | / | Flash Point | 374.3ºC |
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Names
| Name | 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one |
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| Synonym | More Synonyms |
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spiclomazine BiologicalActivity
| Description | Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Ras |
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| Target | KRAS(G12C) |
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| References | [1]. Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951. |
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Chemical & Physical Properties
| Density | 1.42g/cm3 |
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| Boiling Point | 695.3ºC at 760mmHg |
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| Molecular Formula | C22H24ClN3OS2 |
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| Molecular Weight | 446.03 |
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| Flash Point | 374.3ºC |
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| Exact Mass | 445.10500 |
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| PSA | 86.18000 |
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| LogP | 5.31960 |
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| Vapour Pressure | 3.51E-19mmHg at 25°C |
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| Index of Refraction | 1.724 |
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| InChIKey | CFOYBMUYCBSDAL-UHFFFAOYSA-N |
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| SMILES | O=C1CSC2(CCN(CCCN3c4ccccc4Sc4ccc(Cl)cc43)CC2)N1 |
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Synonyms
| Spiclomazine [INN] |
| Clospirazine |
| Spiclomazinum [INN-Latin] |
| Spiclomazinum |
| Espiclomazina |
| Spiclomazine |
