CAS 27013-91-8|alpha-Hederin
| Common Name | alpha-Hederin | ||
|---|---|---|---|
| CAS Number | 27013-91-8 | Molecular Weight | 750.956 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 849.6±65.0 °C at 760 mmHg |
| Molecular Formula | C41H66O12 | Melting Point | 215ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | 250.7±27.8 °C |
Names
| Name | kalopanaxsaponin A |
|---|---|
| Synonym | More Synonyms |
alpha-Hederin BiologicalActivity
| Description | alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation，In vitro: a-hederin is cytotoxic and inhibits proliferation in bothcel lines at rather low concentrations. , a-hederin reduces themitotic activity in treated cels.[1]In vivo: alpha-hederin had preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses. [2] |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersNatural Products >>Terpenoids and GlycosidesResearch Areas >>Others |
| References | [1]. Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60(1):45-9. [2]. Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60(1):45-9. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 849.6±65.0 °C at 760 mmHg |
| Melting Point | 215ºC (dec.) |
| Molecular Formula | C41H66O12 |
| Molecular Weight | 750.956 |
| Flash Point | 250.7±27.8 °C |
| Exact Mass | 750.455444 |
| PSA | 195.60000 |
| LogP | 8.37 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.601 |
| InChIKey | KEOITPILCOILGM-JAVOQYPHSA-N |
| SMILES | CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)O)CCC45C)C3(C)CO)OCC(O)C2O)C(O)C(O)C1O |
| Storage condition | 2~8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980
Safety Information
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | 22 |
| Safety Phrases | 22-45-24/25 |
| RIDADR | UN 1544 |
| RTECS | RK0177800 |
Articles25
More Articles| Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin. J. Biol. Chem. 288(20) , 14000-17, (2013) The interactions of triterpenoid monodesmosidic saponins, α-hederin and δ-hederin, with lipid membranes are involved in their permeabilizing effect. Unfortunately, the interactions of these saponins w... | |
| Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors. Biochemistry 48(15) , 3477-82, (2009) Hederacoside C, alpha-hederin, and hederagenin are saponins of dry extracts obtained from the leaves of ivy (Hedera helix L.). Internalization of beta(2)-adrenergic receptor-GFP fusion proteins after ... | |
| Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips. Phytomedicine 19(7) , 591-5, (2012) The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently prove... |
Synonyms
| α-Hederin |
| (3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid |
| Alpha-hederin |
| glycosidel-e1 |
| Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)- |
| UNII:4H15F0GLV2 |
| sapindosidea |
| HELIXIN |
| nepalin2 |
| dipsacobioside |
| Hederoside B |
| koronaroside A |
| hederosidec |
| akebosidestc |
| taurosidee |
| A-HEDERIN |
| SAPINDOSIDE A |
| HEDERIN |
| Hederin, α- |
| alpha-Hederin |
