CAS 2210-63-1|Mofebutazone

[1]. F.T. Delbeke, et al. Determination of mofebutazone and its 4-hydroxy metabolite in plasma and urine by high-performance liquid chromatography. Journal of Chromatography A. Volume 369, 1986, Pages 440-444

[2]. Khayyal MT,et al. Tolerability of mofebutazone in asthmatic patients. Int J Clin Pharmacol Res. 1995;15(4):145-51.  

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UQ8420000

CHEMICAL NAME :

3,5-Pyrazolidinedione, 4-butyl-1-phenyl-

CAS REGISTRY NUMBER :

2210-63-1

BEILSTEIN REFERENCE NO. :

0213056

LAST UPDATED :

199612

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C13-H16-N2-O2

MOLECULAR WEIGHT :

232.31

WISWESSER LINE NOTATION :

T5VMNV EHJ CR& E4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 39,155,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

848 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,347,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

700 mg/kg

TOXIC EFFECTS :

Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

920 mg/kg

TOXIC EFFECTS :

Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 233,365,1958