CAS 60-18-4|L-Tyrosine
Introduction：Basic information about CAS 60-18-4|L-Tyrosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Tyrosine | ||
|---|---|---|---|
| CAS Number | 60-18-4 | Molecular Weight | 181.189 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 385.2±32.0 °C at 760 mmHg |
| Molecular Formula | C9H11NO3 | Melting Point | >300 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 186.7±25.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | L-tyrosine |
|---|---|
| Synonym | More Synonyms |
L-Tyrosine BiologicalActivity
| Description | L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Results show that L-Tyrosine in vitro inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM), hippocampus (1.0, 2.0 and 4.0 mM), striatum (4.0 mM) and liver (0.1, 1.0, 2.0 and 4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0, 2.0 and 4.0 mM) following treatment with L-Tyrosine[1]. |
| In Vivo | The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1]. |
| Kinase Assay | Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II–III and IV are evaluated[1]. |
| Animal Admin | The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1]. |
| References | [1]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 385.2±32.0 °C at 760 mmHg |
| Melting Point | >300 °C (dec.)(lit.) |
| Molecular Formula | C9H11NO3 |
| Molecular Weight | 181.189 |
| Flash Point | 186.7±25.1 °C |
| Exact Mass | 181.073898 |
| PSA | 83.55000 |
| LogP | 0.38 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | OUYCCCASQSFEME-QMMMGPOBSA-N |
| SMILES | NC(Cc1ccc(O)cc1)C(=O)O |
| Water Solubility | 0.45 g/L (25 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/2W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20750 mg/kg
- SEX/DURATION :
- female 15-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 gm/kg
- SEX/DURATION :
- female 11-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3500 mg/kg
- SEX/DURATION :
- female 15-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 29-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81869 No. of Facilities: 133 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1421 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81869 No. of Facilities: 275 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14731 (estimated) No. of Female Employees: 12371 (estimated)
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81869 No. of Facilities: 133 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1421 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81869 No. of Facilities: 275 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14731 (estimated) No. of Female Employees: 12371 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YP2275600 |
| HS Code | 29225000 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| L-tyrosine zwitterion |
| hydrogen L-tyrosinate |
| MEVINOLIN |
| LOVALIP |
| a-Amino-p-hydroxyhydrocinnamic Acid |
| L-Phenylalanine, 4-hydroxy- |
| LOVASTIN |
| MEVACOR |
| H-Tyr-OH |
| Tyrosine |
| MFCD00002606 |
| L-Tyr |
| Rovacor |
| Tyr |
| (S)-(-)-Tyrosine |
| Sivlor |
| L-Tyrosine |
| (S)-a-Amino-4-hydroxybenzenepropanoic acid |
| Tyrosine, L- |
| b-(p-Hydroxyphenyl)alanine |
| mevlor |
| Benzenepropanoic acid, α-amino-4-hydroxy-, (S)- |
| Tyrosinum [Latin] |
| (S)-a-amino-4-hydroxy-Benzenepropanoic acid |
| (S)-tyrosine |
| (S)-α-amino-4-hydroxy-Benzenepropanoic acid |
| EINECS 200-460-4 |
| msd803 |
| Paschol |
