CAS 465-65-6|Naloxone
Introduction：Basic information about CAS 465-65-6|Naloxone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Naloxone | ||
|---|---|---|---|
| CAS Number | 465-65-6 | Molecular Weight | 327.37 |
| Density | 1.43 g/cm3 | Boiling Point | 532.8ºC at 760 mmHg |
| Molecular Formula | C19H21NO4 | Melting Point | 184ºC |
| MSDS | / | Flash Point | 276.1ºC |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | naloxone |
|---|---|
| Synonym | More Synonyms |
Naloxone BiologicalActivity
| Description | Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease |
| References | [1]. van Dorp E, et al. Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32. |
Chemical & Physical Properties
| Density | 1.43 g/cm3 |
|---|---|
| Boiling Point | 532.8ºC at 760 mmHg |
| Melting Point | 184ºC |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.37 |
| Flash Point | 276.1ºC |
| Exact Mass | 327.14700 |
| PSA | 70.00000 |
| LogP | 1.23930 |
| InChIKey | UZHSEJADLWPNLE-GRGSLBFTSA-N |
| SMILES | C=CCN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3(O)C1C5 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 16-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 120 umol/L/24H
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,519,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4324 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 306 (estimated) No. of Female Employees: 121 (estimated)
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 120 umol/L/24H
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,519,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4324 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 306 (estimated) No. of Female Employees: 121 (estimated)
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
Articles72
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Synonyms
| [14C]-Naloxone |
| [3H]-Naloxone |
| Narcanti |
| Nalone |
| Naloxonum |
| EN 1530 base |
| (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one |
| Narcon |
| l-Naloxone |
| Narcan |
| n-Allylnoroxymorphone |
| Naloxona |
