CAS 10138-52-0|gadolinium chloride
Introduction：Basic information about CAS 10138-52-0|gadolinium chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | gadolinium chloride | ||
|---|---|---|---|
| CAS Number | 10138-52-0 | Molecular Weight | 263.60900 |
| Density | 4.52 | Boiling Point | 1580ºC |
| Molecular Formula | Cl3Gd | Melting Point | 609ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | gadolinium trichloride |
|---|---|
| Synonym | More Synonyms |
gadolinium chloride BiologicalActivity
| Description | Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>CaSR |
| Target | CaSR[1] |
| In Vitro | Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1]. In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1]. Western Blot Analysis[1] Cell Line: H9c2 cells Concentration: 30 μM Incubation Time: 15 minutes Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells. |
| References | [1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801. |
Chemical & Physical Properties
| Density | 4.52 |
|---|---|
| Boiling Point | 1580ºC |
| Melting Point | 609ºC |
| Molecular Formula | Cl3Gd |
| Molecular Weight | 263.60900 |
| Exact Mass | 262.83100 |
| LogP | 2.06850 |
| Vapour Pressure | 33900mmHg at 25°C |
| InChIKey | MEANOSLIBWSCIT-UHFFFAOYSA-K |
| SMILES | Cl[Gd](Cl)Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 378 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,437,1962 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R38 |
| Safety Phrases | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | ZC0230000 |
Articles47
More Articles| Nd(3+)-Sensitized Ho(3+) Single-Band Red Upconversion Luminescence in Core-Shell Nanoarchitecture. J. Phys. Chem. Lett. 6 , 2833-40, (2015) A strategy to achieve 808 nm excited single-band red upconversion luminescence of Ho(3+) via the core-shell nanoarchitecture design was provided. Specifically, the synthesized Yb/Ho/Ce: NaGdF4@Yb/Nd: ... | |
| Yttrium oxide/gadolinium oxide-modified platinum nanoparticles as cathodes for the oxygen reduction reaction. ChemPhysChem 15(10) , 2136-44, (2014) Rare-earth-element (Y, Gd) modified Pt nanoparticles (NPs) supported on a carbon substrate (Vulcan XC-72) are synthesized via a water-in-oil chemical route. In both cases, X-ray diffraction (XRD) meas... | |
| Mechanosensitive store-operated calcium entry regulates the formation of cell polarity. J. Cell Physiol. 230 , 2086-97, (2015) Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role ... |
Synonyms
| trichlorogadolinium |
| EINECS 233-386-6 |
| Gadolinium(Iii) Chloride,Ultra Dry,Reo) |
| Gadolinium(III) chloride |
| MFCD00011024 |
