Introduction：Basic information about CAS 526-06-7|Eudesmin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Eudesmin |
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| CAS Number | 526-06-7 | Molecular Weight | 386.438 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 517.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H26O6 | Melting Point | 108.5-109.5℃ |
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| MSDS | / | Flash Point | 209.8±30.0 °C |
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Names
| Name | 1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1.α.,3a.α.,4.α.,6a.α.)-(-) |
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| Synonym | More Synonyms |
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Eudesmin BiologicalActivity
| Description | Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK) |
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| Target | S6K1[1] |
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| In Vitro | Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1]. |
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| References | [1]. Ki Hong Nam, et al. Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 517.3±50.0 °C at 760 mmHg |
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| Melting Point | 108.5-109.5℃ |
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| Molecular Formula | C22H26O6 |
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| Molecular Weight | 386.438 |
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| Flash Point | 209.8±30.0 °C |
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| Exact Mass | 386.172943 |
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| PSA | 55.38000 |
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| LogP | 3.08 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.547 |
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| InChIKey | PEUUVVGQIVMSAW-UHFFFAOYSA-N |
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| SMILES | COc1ccc(C2OCC3C(c4ccc(OC)c(OC)c4)OCC23)cc1OC |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22 |
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| Safety Phrases | 36 |
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Synonyms
| Pinoresinol dimethyl ether |
| Eudesamin,Eudesmin |
| (1S,3aR,4S,6aR)-1,4-Bis(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan |
| 1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1S,3aR,4S,6aR)- |
| (7S,7’S,8R,8’R)-eudesmin |
| (1S,3aR,4S,6aR)-1,4-bis(3,4-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan |
| eudesmin |
