Introduction：Basic information about CAS 50298-90-3|Cucurbitacin IIB, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cucurbitacin IIB |
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| CAS Number | 50298-90-3 | Molecular Weight | 520.698 |
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| Density | 1.22±0.1 g/cm3 | Boiling Point | 668.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O7 | Melting Point | 158-159ºC |
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| MSDS | / | Flash Point | 372.0±28.0 °C |
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Names
| Name | Cucurbitacin IIB |
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| Synonym | More Synonyms |
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Cucurbitacin IIB BiologicalActivity
| Description | Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/Immunology |
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| References | [1]. Wang Y, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9(2):e89751. |
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Chemical & Physical Properties
| Density | 1.22±0.1 g/cm3 |
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| Boiling Point | 668.4±55.0 °C at 760 mmHg |
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| Melting Point | 158-159ºC |
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| Molecular Formula | C30H48O7 |
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| Molecular Weight | 520.698 |
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| Flash Point | 372.0±28.0 °C |
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| Exact Mass | 520.340027 |
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| PSA | 135.29000 |
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| LogP | 1.92 |
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| Vapour Pressure | 0.0±4.6 mmHg at 25°C |
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| Index of Refraction | 1.577 |
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| InChIKey | VVBWBGOEAVGFTN-LPQIEKFGSA-N |
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| SMILES | CC(C)(O)CCC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(O)C4(C)C)C3(C)C(=O)CC12C |
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| Storage condition | 2-8°C |
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Synonyms
| 19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)- |
| (1S,2S,4R,9β,16α)-1,2,16,20,25-Pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione |
| 25-deacetyl hemslecin A |
| 22,23-dihydrocucurbitacin F |
| Estr-5-en-11-one, 17-[(1R)-1,5-dihydroxy-1,5-dimethyl-2-oxohexyl]-2,3,16-trihydroxy-4,4,9,14-tetramethyl-, (2β,3α,9β,10α,16α,17β)- |
| 23,24-Dihydrocucurbitacin F |
| dihydrocucurbitacin F |
| CucurbitacinⅡb |
| Cucurbitacin Ⅱb |
