Introduction：Basic information about CAS 101314-97-0|Simvastatin Hydroxy Acid Sodium Salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Simvastatin Hydroxy Acid Sodium Salt |
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| CAS Number | 101314-97-0 | Molecular Weight | 458.563 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C25H39NaO6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate |
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| Synonym | More Synonyms |
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Simvastatin Hydroxy Acid Sodium Salt BiologicalActivity
| Description | Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Research Areas >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1]. Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1]. |
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| In Vivo | Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1]. |
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| References | [1]. Corsini A, et al. Pharmacology of competitive inhibitors of HMG-CoA reductase.Pharmacol Res. 1995 Jan;31(1):9-27. |
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Chemical & Physical Properties
| Molecular Formula | C25H39NaO6 |
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| Molecular Weight | 458.563 |
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| Exact Mass | 458.264435 |
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| PSA | 106.89000 |
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| LogP | 2.77100 |
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| InChIKey | SVIXZYADIXSPPP-OKDJMAGBSA-N |
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| SMILES | CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)O)C21.[Na] |
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Synonyms
| Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate |
| Simvastatin Hydroxy Acid Sodium Salt |
| simvastatin sodium |
| Si-Methyl-N,N'N''-triphenyl-silantriyltriamin |
| 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1) |
| trianilino-methyl-silane |
| simvastatin sodium salt |
| Silanetriamine,1-methyl-N,N',N''-triphenyl |
| Methyl-tris-anilino-silan |
| simivastin sodium salt |
| Simvastatin EP Impurity A Sodium Salt |
| Simvastatin Impurity 1 |
