Introduction：Basic information about CAS 179386-44-8|Sumanirole Maleate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sumanirole Maleate |
|---|
| CAS Number | 179386-44-8 | Molecular Weight | 319.313 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C15H17N3O5 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | Sumanirole maleate |
|---|
| Synonym | More Synonyms |
|---|
Sumanirole Maleate BiologicalActivity
| Description | Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
|---|
| References | [1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587 |
|---|
Chemical & Physical Properties
| Molecular Formula | C15H17N3O5 |
|---|
| Molecular Weight | 319.313 |
|---|
| Exact Mass | 319.116821 |
|---|
| PSA | 124.42000 |
|---|
| LogP | 0.57640 |
|---|
| InChIKey | VOJRMYBBPKNLLI-ORHWHDKWSA-N |
|---|
| SMILES | CNC1Cc2cccc3[nH]c(=O)n(c23)C1.O=C(O)C=CC(=O)O |
|---|
| Storage condition | -20℃ |
|---|
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles1
More Articles
| Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains. Behav. Brain Res. 274 , 1-9, (2014) The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in com... | |
Synonyms
| cc-479 |
| (5R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1) |
| 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one, 5,6-dihydro-5-(methylamino)-, (5R)-, (2Z)-2-butenedioate (1:1) |
| UNII-2OI87T3R1B |
| S2191_Selleck |
| Sumanirole (maleate) |
