CAS 179528-45-1|PD150606

Introduction：Basic information about CAS 179528-45-1|PD150606, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. PD150606 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	PD150606
CAS Number	179528-45-1	Molecular Weight	306.120
Density	1.9±0.1 g/cm3	Boiling Point	410.4±45.0 °C at 760 mmHg
Molecular Formula	C₉H₇IO₂S	Melting Point	/
MSDS	ChineseUSA	Flash Point	202.0±28.7 °C
Symbol	GHS05, GHS06	Signal Word	Danger

Names

Name	(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
Synonym	More Synonyms

PD150606 BiologicalActivity

Description	PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).target:calpain[1]In vitro: PD150606 also against tetrafluoroethyl-l-cysteine-, bromohydroquinone-, oxidant (t-butylhydroperoxide)- and calcium ionophore (ionomycin)-induced cell death. PD150606 inhibits calpains by binding to the calcium-binding domain of the enzyme. [2] high specificity for calpains relative to other proteases, uncompetitive inhibition with respect to substrate.[3]
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Cancer
References	[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. [2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84. [3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

Description

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).target:calpain[1]In vitro: PD150606 also against tetrafluoroethyl-l-cysteine-, bromohydroquinone-, oxidant (t-butylhydroperoxide)- and calcium ionophore (ionomycin)-induced cell death. PD150606 inhibits calpains by binding to the calcium-binding domain of the enzyme. [2] high specificity for calpains relative to other proteases, uncompetitive inhibition with respect to substrate.[3]

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Cancer

References

[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9.

[2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.

[3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

Chemical & Physical Properties

Density	1.9±0.1 g/cm3
Boiling Point	410.4±45.0 °C at 760 mmHg
Molecular Formula	C₉H₇IO₂S
Molecular Weight	306.120
Flash Point	202.0±28.7 °C
Exact Mass	305.921143
PSA	76.10000
LogP	4.25
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.732
InChIKey	DJCVSFWGKYHMKH-YVMONPNESA-N
SMILES	O=C(O)C(S)=Cc1ccc(I)cc1
Storage condition	2-8℃

Safety Information

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H317-H318-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338
RIDADR	UN 2811 6.1 / PGIII

Articles1

Improved performance of aminopropylsilatrane over aminopropyltriethoxysilane as an adhesive film for anchoring gold nanoparticles on silicon surfaces.

J. Nanosci. Nanotechnol. 9 , 2894-901, (2009)

Aminopropylsilatrane (AP-silatrane) was investigated as an adhesive layer for anchoring Au nanoparticles on silicon substrates. We compared the preparation procedure and film quality of the AP-silatra...

Synonyms

(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid

PD150606

(2Z)-3-(4-Iodophenyl)-2-sulfanylacrylic acid

(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid

2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)-

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