CAS 88191-84-8|Calpain Inhibitor III
| Common Name | Calpain Inhibitor III | ||
|---|---|---|---|
| CAS Number | 88191-84-8 | Molecular Weight | 382.45 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 450.4±45.0 °C at 760 mmHg |
| Molecular Formula | C22H26N2O4 | Melting Point | / |
| MSDS | USA | Flash Point | 226.2±28.7 °C |
Names
| Name | Z-Val-Phe-H |
|---|---|
| Synonym | More Synonyms |
Calpain Inhibitor III BiologicalActivity
| Description | cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| Target | Calpain[1]. |
| In Vitro | MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization[1]. MDL-28170 dose-dependently inhibits brain cysteine proteinase activity (in vitro Ki= 0.01 μM)[2]. |
| In Vivo | Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively[2]. MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury[3]. MDL-28170 (10 mg/kg, i.p.) significantly improves nerve function parameters in diabetic rats. MDL-28170 (3 and 10 mg/kg, i.p.) improves nociceptive behavior in diabetic rats[5]. |
| References | [1]. Chen ZF, et al. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res. 1997 Sep 19;769(1):188-92. [2]. Li PA, et al. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci Lett. 1998 May 8;247(1):17-20. [3]. Ai J, et al. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma. 2007 Jun;24(6):960-78. [4]. De Strooper B, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. [5]. Kharatmal SB, et al. Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy. Neuropharmacology. 2015 Oct;97:113-21. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 450.4±45.0 °C at 760 mmHg |
| Molecular Formula | C22H26N2O4 |
| Molecular Weight | 382.45 |
| Flash Point | 226.2±28.7 °C |
| PSA | 84.50000 |
| LogP | 3.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.571 |
| InChIKey | NGBKFLTYGSREKK-UHFFFAOYSA-N |
| SMILES | CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(C=O)Cc1ccccc1 |
| Storage condition | 2-8℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
Articles34
More Articles| Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons. Int. J. Mol. Sci. 16 , 15659-69, (2015) Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ... | |
| A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat. Commun. 5 , 5683, (2014) Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contus... | |
| Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J. Neurosci. 35(2) , 621-33, (2015) Deciphering and storing information coded in different firing patterns are important properties of neuronal networks, as they allow organisms to respond and adapt to external and internal events. Here... |
Synonyms
| CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO |
| MFCD00798796 |
| Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-phenylethyl]amino]carbonyl]-2-methylpropyl]-, phenylmethyl ester |
| Carbamic acid, N-[(1S)-1-formyl-2-phenylethyl]-, phenylmethyl ester |
| N-benzyloxycarbonyl-(S)-valinylphenylalaninal |
| benzyl [(2S)-1-oxo-3-phenylpropan-2-yl]carbamate |
| Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}butan-2-yl]carbamate |
| Z-Val-Phe-H |
| Z-VAL-PHE-CHO |
| (S)-(-)-2-(Benzylcarbonylamino)-3-phenylpropanal |
| Z-L-Val-L-Phe-OH |
| Benzyl [(2S)-1-oxo-3-phenyl-2-propanyl]carbamate |
| CARBOBENZOXY-VALINYL-PHENYLALANINAL |
| CALPAIN INHIBITOR III |
| Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenyl-2-propanyl]amino}-2-butanyl]carbamate |
| Cbz-L-Val-L-Phe-OH |
| Z-VAL-PHE-ALDEHYDE |
| MDL 28170 |
| MDL-28170 |
