CAS 300586-90-7|OAC1

Introduction：Basic information about CAS 300586-90-7|OAC1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameOAC1
CAS Number300586-90-7Molecular Weight237.257
Density1.4±0.1 g/cm3Boiling Point386.6±22.0 °C at 760 mmHg
Molecular FormulaC14H11N3OMelting Point/
MSDS/Flash Point187.6±22.3 °C

Names

Nameoac1
SynonymMore Synonyms

OAC1 BiologicalActivity

DescriptionOAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.IC50 value: Target: Oct4 activatorin vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.
Related CatalogSignaling Pathways >>Stem Cell/Wnt >>Oct3/4Research Areas >>Others
References

[1]. Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point386.6±22.0 °C at 760 mmHg
Molecular FormulaC14H11N3O
Molecular Weight237.257
Flash Point187.6±22.3 °C
Exact Mass237.090210
PSA57.78000
LogP1.19
Vapour Pressure0.0±0.9 mmHg at 25°C
Index of Refraction1.755
InChIKeyHWJRIFZDXJKJJN-UHFFFAOYSA-N
SMILESO=C(Nc1cc2cc[nH]c2cn1)c1ccccc1

Safety Information

RIDADRNONH for all modes of transport

Synonyms

N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide
Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-
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