Introduction：Basic information about CAS 77521-29-0|(RS)-AMPA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (RS)-AMPA |
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| CAS Number | 77521-29-0 | Molecular Weight | 186.165 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 425.6±45.0 °C at 760 mmHg |
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| Molecular Formula | C7H10N2O4 | Melting Point | 240ºC |
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| MSDS | / | Flash Point | 211.2±28.7 °C |
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Names
| Name | (r,s)-ampa |
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| Synonym | More Synonyms |
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(RS)-AMPA BiologicalActivity
| Description | (RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vitro | (RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1]. |
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| References | [1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 425.6±45.0 °C at 760 mmHg |
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| Melting Point | 240ºC |
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| Molecular Formula | C7H10N2O4 |
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| Molecular Weight | 186.165 |
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| Flash Point | 211.2±28.7 °C |
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| Exact Mass | 186.064056 |
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| PSA | 109.58000 |
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| LogP | -0.44 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.579 |
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| InChIKey | UUDAMDVQRQNNHZ-UHFFFAOYSA-N |
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| SMILES | Cc1o[nH]c(=O)c1CC(N)C(=O)O |
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Safety Information
Synonyms
| ampa |
| 3-(5-Méthyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanine |
| UNII:J090588E6X |
| 2-Amino-3-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid |
| 3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanine |
| 3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanin |
| ampa hbr |
| 2-ammonio-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoate |
| 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo- |
