CAS 94470-67-4|Cromakalim
| Common Name | Cromakalim | ||
|---|---|---|---|
| CAS Number | 94470-67-4 | Molecular Weight | 286.33 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 482.3±45.0 °C at 760 mmHg |
| Molecular Formula | C16H20N2O3S | Melting Point | 242-244ºC |
| MSDS | USA | Flash Point | 245.5±28.7 °C |
Names
| Name | (±)-Cromakalim |
|---|---|
| Synonym | More Synonyms |
Cromakalim BiologicalActivity
| Description | Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| References | [1]. Cortijo J, et al. The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;346(4):462-468. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 482.3±45.0 °C at 760 mmHg |
| Melting Point | 242-244ºC |
| Molecular Formula | C16H20N2O3S |
| Molecular Weight | 286.33 |
| Flash Point | 245.5±28.7 °C |
| Exact Mass | 286.131744 |
| PSA | 73.56000 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| InChIKey | TVZCRIROJQEVOT-LSDHHAIUSA-N |
| SMILES | CC1(C)Oc2ccc(C#N)cc2C(N2CCCC2=O)C1O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
Articles30
More Articles| The relaxant action of nicorandil in bovine tracheal smooth muscle. Pharmacology 89(5-6) , 327-32, (2012) The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. In preparations contracted with methach... | |
| CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R1003-10, (2012) Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hy... | |
| Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: effect of potassium channel modulators. Eur. J. Pharmacol. 660(2-3) , 431-7, (2011) Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+)... |
Synonyms
| (3R,4S)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromanecarbonitrile |
| (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile |
| 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)- |
| (+)-Cromakalim |
