CAS 60311-02-6|Sulforhodamine 101
| Common Name | Sulforhodamine 101 | ||
|---|---|---|---|
| CAS Number | 60311-02-6 | Molecular Weight | 606.70900 |
| Density | 1.1982 (rough estimate) | Boiling Point | / |
| Molecular Formula | C31H30N2O7S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | sulforhodamine 101 |
|---|---|
| Synonym | More Synonyms |
Sulforhodamine 101 BiologicalActivity
| Description | Sulforhodamine 101 is a red fluorescent dye. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological DiseaseDye Reagents |
| In Vitro | Sulforhodamine 101 does not label astrocytes in brainstem slices as strong and specific as in the hippocampus or cortex. To minimize excitatory side effects, the concentration of Sulforhodamine 101 has to be kept as low as possible or the labeling procedure can be performed after the actual experiment[1]. |
| In Vivo | In vivo, epileptic activity can be induced by intra-hippocampal injection of small volumes of 10 μM Sulforhodamine 101 or topical application of 100 μM[1]. |
| Cell Assay | Acute brain slices are usually incubated in carbonated extracellular solution containing 0.5 to1 μM Sulforhodamine 101 for 20 to 30 min and 34 to 37°C. Following this, excess dye is removed over a period of 10 to 30 min using different protocols that were described earlier[1]. |
| Animal Admin | For in vivo imaging, Sulforhodamine 101 (SR101) is applied topically at concentrations of 250 nM to 300 μM or by bolus injection. Additionally, Sulforhodamine 101 injection over the tail vein (10 mg/mL) has been reported to be successful[1]. |
| References | [1]. Hülsmann S, et al. Limitations of Sulforhodamine 101 for Brain Imaging. Front Cell Neurosci. 2017 Feb 28;11:44. |
Chemical & Physical Properties
| Density | 1.1982 (rough estimate) |
|---|---|
| Molecular Formula | C31H30N2O7S2 |
| Molecular Weight | 606.70900 |
| Exact Mass | 606.14900 |
| PSA | 143.81000 |
| LogP | 4.59910 |
| Index of Refraction | 1.6900 (estimate) |
| InChIKey | COIVODZMVVUETJ-UHFFFAOYSA-N |
| SMILES | O=S(=O)([O-])c1cc(S(=O)(=O)O)ccc1C1=c2cc3c4c(c2Oc2c1cc1c5c2CCCN5CCC1)CCC[N+]=4CCC3 |
| Water Solubility | methanol: soluble1mg/mL |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 32049090 |
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Synonyms
| sulforhodamine |
| MFCD00012407 |
| Sulforhodamine-101 |
| EINECS 262-159-4 |
| Texas Red,Sulforhodamine 101 Acid Chloride |
| 2-(2,3,6,7,12,13,16,17-octahydro-1h,5h,11h,15h-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)-5-sulfobenzenesulfonate |
