Introduction：Basic information about CAS 888719-03-7|BMS-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BMS-2 |
|---|
| CAS Number | 888719-03-7 | Molecular Weight | 458.416 |
|---|
| Density | 1.5±0.1 g/cm3 | Boiling Point | 701.5ºC at 760 mmHg |
|---|
| Molecular Formula | C25H16F2N4O3 | Melting Point | 212-214ºC |
|---|
| MSDS | / | Flash Point | 378.1ºC |
|---|
Names
| Name | 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxopyridine-3-carboxamide |
|---|
| Synonym | More Synonyms |
|---|
BMS-2 BiologicalActivity
| Description | MET kinase-IN-4 is an orally active Met kinase inhibitor. MET kinase-IN-4 has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM. MET kinase-IN-4 can be used for the research of cancer[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>c-Met/HGFR |
|---|
| Target | IC50: 1.9 nM (Met); 4 nM (Flt-3); 27 nM (VEGFR-2)[1] |
|---|
| In Vitro | MET kinase-IN-4 (Compound 2) 具有有效的 Met 激酶抑制活性，IC50 值为 1.9 nM[1]。 MET kinase-IN-4 抑制 Flt-3 和 VEGFR-2 激酶，IC50 值分别为 4 和 27 nM[1]。 MET kinase-IN-4 (3 μM) 在人和小鼠肝微粒体中表现出良好的代谢稳定性[1]。 |
|---|
| In Vivo | MET kinase-IN-4 (Compound 2) 在小鼠体内具有良好的药代动力学特征[1]。 MET kinase-IN-4 在 GTL-16 人胃癌异种移植模型中表现出显著的体内抗肿瘤活性[1]。 Animal Model: Mice[1] Dosage: 5, 10 mg/kg Administration: IV, PO Result: Showed extensive extravascular distribution and a favorable half-life. Animal Model: Nude mice[1] Dosage: 6.25, 12.5, 25 and 50 mg/kg Administration: PO, once a day Result: Showed antitumor activity in dose-dependet. |
|---|
| References | [1]. Kyoung Soon Kim, et al. Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2008 Sep 11;51(17):5330-41. |
|---|
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|
| Boiling Point | 701.5ºC at 760 mmHg |
|---|
| Melting Point | 212-214ºC |
|---|
| Molecular Formula | C25H16F2N4O3 |
|---|
| Molecular Weight | 458.416 |
|---|
| Flash Point | 378.1ºC |
|---|
| Exact Mass | 458.119049 |
|---|
| PSA | 89.01000 |
|---|
| LogP | 4.82 |
|---|
| Index of Refraction | 1.721 |
|---|
| InChIKey | OBSFXHDOLBYWRJ-UHFFFAOYSA-N |
|---|
| SMILES | O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O |
|---|
Synonyms
| 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydro-3-pyridinecarboxamide |
| RS0065 |
| 3ce3 |
| 2-pyridone analogue,2 |
| N-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide |
| 3-Pyridinecarboxamide, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo- |
