Introduction：Basic information about CAS 69120-06-5|5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol |
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| CAS Number | 69120-06-5 | Molecular Weight | 310.344 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 439.4±35.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O4 | Melting Point | / |
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| MSDS | / | Flash Point | 219.6±25.9 °C |
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Names
| Name | 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
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| Target | COX-2 |
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| In Vitro | Moracin C (1-50 μM，24 小时) 抑制 RAW264.7 细胞释放 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO)[1]。 Moracin C (1-50 μM, 2 h) 抑制 RAW264.7 细胞中 iNOS 和 COX-2 的 mRNA 和蛋白表达[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中促炎细胞因子 (IL-1β、IL-6 和 TNF-α) 的产生[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中 p38、ERK 和 JNK 的磷酸化[1]。 RT-PCR[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels. |
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| In Vivo | Moracin C (100 mg/kg，灌胃，小鼠) 在肠道内吸收迅速、吸收良好，在胃肠道、肝脏、肾脏和肺部分布较广[2]。 Animal Model: Mice (PK Assay)[2] Dosage: 100 mg/kg Administration: Oral gavage Result: Pharmacokinetic profile of Moracin C. Parameters Terminal half-life (min) Cmax (μg/mL) Tmax (min) CLR (mL/min/kg) 100 mg/kg 256 1.79 15 0.032 |
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| References | [1]. Yao X, et al. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199. [2]. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 439.4±35.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O4 |
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| Molecular Weight | 310.344 |
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| Flash Point | 219.6±25.9 °C |
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| Exact Mass | 310.120514 |
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| PSA | 73.83000 |
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| LogP | 4.46 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.664 |
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| InChIKey | ZTGHWUWBQNCCOH-UHFFFAOYSA-N |
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| SMILES | CC(C)=CCc1c(O)cc(-c2cc3ccc(O)cc3o2)cc1O |
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Safety Information
Synonyms
| Moracin C |
| 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)- |
| 5-(6-Hydroxy-1-benzofuran-2-yl)-2-(3-methyl-2-buten-1-yl)-1,3-benzenediol |
| 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)- |
| 5-(6-Hydroxy-benzofuran-2-yl)-2-(3-methyl-but-2-enyl)-benzene-1,3-diol |
