Introduction：Basic information about CAS 62949-79-5|Mulberrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mulberrin |
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| CAS Number | 62949-79-5 | Molecular Weight | 422.470 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 657.7±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H26O6 | Melting Point | 153-156 °C |
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| MSDS | / | Flash Point | 225.0±25.0 °C |
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Names
| Name | 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methylbut-2-enyl)chromen-4-one |
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| Synonym | More Synonyms |
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Mulberrin BiologicalActivity
| Description | Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM. |
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| Related Catalog | Signaling Pathways >>Others >>OthersNatural Products >>FlavonoidsResearch Areas >>Cardiovascular Disease |
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| In Vitro | Mulberrin is a flavone with two isopentenyl groups at positions 3 and 8. Mulberrin is a strong inhibitor of OATP2B1 with more than 80% inhibition.Mulberrin also inhibits organic anion-transporting polypeptide (OATP)-mediated uptake of Atorvastatin, Fluvastatin, and Rosuvastatin[1]. |
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| References | [1]. Wen F, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 657.7±55.0 °C at 760 mmHg |
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| Melting Point | 153-156 °C |
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| Molecular Formula | C25H26O6 |
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| Molecular Weight | 422.470 |
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| Flash Point | 225.0±25.0 °C |
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| Exact Mass | 422.172943 |
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| PSA | 111.13000 |
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| LogP | 5.78 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.642 |
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| InChIKey | UWQYBLOHTQWSQD-UHFFFAOYSA-N |
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| SMILES | CC(C)=CCc1c(-c2ccc(O)cc2O)oc2c(CC=C(C)C)c(O)cc(O)c2c1=O |
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| Storage condition | 2-8°C |
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Synonyms
| Norartocarpin |
| 2-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-8-((Z)-3-methyl-but-2-enyl)-3-(3-methyl-but-2-enyl)-1-benzopyran-4-one |
| 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)- |
| Kuwanon C |
