CAS 1093222-27-5|Pim1/AKK1-IN-1

Introduction：Basic information about CAS 1093222-27-5|Pim1/AKK1-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pim1/AKK1-IN-1 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Pim1/AKK1-IN-1
CAS Number	1093222-27-5	Molecular Weight	339.35000
Density	1.42	Boiling Point	/
Molecular Formula	C₂₀H₁₃N₅O	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
Synonym	More Synonyms

Pim1/AKK1-IN-1 BiologicalActivity

Description	Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Related Catalog	Signaling Pathways >>JAK/STAT Signaling >>PimResearch Areas >>Cancer
Target	Kd: 35 nM (Pim1), 53 nM (AKK1), 75 nM (MST2), 380 nM (LKB1)
In Vitro	Pim1/AKK1-IN-1 is multi-kinase inhibitor, and has Kd of 380 nM against LKB1 and 53 nM against AAK1[1].
References	[1]. Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.

Chemical & Physical Properties

Density	1.42
Molecular Formula	C₂₀H₁₃N₅O
Molecular Weight	339.35000
Exact Mass	339.11200
PSA	97.95000
LogP	4.13288
InChIKey	JTSLALYXYSRPGW-UHFFFAOYSA-N
SMILES	N#Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1
Storage condition	2-8℃

Synonyms

3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]

CS-0342

LKB1 (AAK1 dual inhibitor)

N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide

LKB1(AAK1 dual inhibitor)||3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]

Pim1/AKK1-IN-1

Recommended......